111477-98-6

Basic information

• Product Name: 7-Fluoro-2,2-diMethylchroMan-4-one
• Synonyms: 7-Fluoro-2,2-diMethylchroMan-4-one;7-fluoro-2,2-diMethyl-3h-chroMen-4-one;7-FLUORO-2,2-DIMETHYL-3,4-DIHYDRO-2H-1-BENZOPYRAN-4-ONE;4H-1-Benzopyran-4-one, 7-fluoro-2,3-dihydro-2,2-dimethyl-
• CAS NO: 111477-98-6
• Molecular Formula: C11H11FO2
• Molecular Weight: 194.2022432
• EINECS: -0
• Mol File: 111477-98-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 282.6±40.0 °C(Predicted)
• Appearance: /
• Density: 1.166±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-Fluoro-2,2-diMethylchroMan-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Fluoro-2,2-diMethylchroMan-4-one(111477-98-6)
• EPA Substance Registry System: 7-Fluoro-2,2-diMethylchroMan-4-one(111477-98-6)

Safety Data

• Hazardous Substances Data: 111477-98-6(Hazardous Substances Data)

Usage

Description

7-Fluoro-2,2-diMethylchroMan-4-one is a chemical compound characterized by its molecular formula C11H11FO2. It is a fluorescent yellow solid that exhibits an aromatic and fruity odor, making it a valuable component in the synthesis of pharmaceuticals and organic compounds. Its unique chemical properties and versatile reactivity in organic reactions contribute to its widespread use in research and development.

Uses

Used in Pharmaceutical Industry:
7-Fluoro-2,2-diMethylchroMan-4-one is used as a building block in the synthesis of various pharmaceuticals for its unique chemical properties and versatile reactivity in organic reactions. It plays a crucial role in the development of new drugs and materials, contributing to advancements in medicine.
Used in Fragrance Industry:
7-Fluoro-2,2-diMethylchroMan-4-one is used as a fragrance ingredient in perfumes and personal care products due to its aromatic and fruity odor. Its distinct scent profile adds depth and complexity to fragrance formulations, enhancing the sensory experience of consumers.
Used in Research and Development:
7-Fluoro-2,2-diMethylchroMan-4-one is utilized in the research and development of new drugs and materials. Its unique chemical properties and versatile reactivity in organic reactions make it an essential tool for scientists and researchers in exploring novel applications and innovations in various fields.

Upstream product

• 541-47-9 3-Methylbutenoic acid 
• 372-20-3 3-fluorophenol 
• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 1481-27-2 4-Fluoro-2-hydroxyacetophenone 
• 67-64-1 acetone 

Downstream Products

• 1202886-85-8 7-(4-(4-chlorophenethylcarbamoyl)phenoxy)-6-cyano-2,2-dimethylchroman-4-carboxylic acid 
• 1202889-84-6 methyl 7-(4-((4-chlorophenethyl)carbamoyl)phenoxy)-6-cyano-2,2-dimethylchroman-4-carboxylate 

Relevant articles and documents

Bismuth(III) triflate catalyzed tandem esterification–Fries–oxa-Michael route to 4-chromanones

An efficient tandem reaction approach is described to prepare 4-chromanones from electron-rich phenols and 3,3-dimethylacrylic acid or trans-crotonic acid in boiling toluene using 20?mol?% bismuth(III) triflate as the catalyst. The reaction is also successful from the corresponding aryl esters of each of these acids under the same conditions. The procedure is convenient to perform, and 25–90% yields of products are realized following chromatography. A range of substrates is included (14 substrates for each acid) to help define the scope of the process. Additional experiments are reported, which confirm that the sequence of events involves (1) esterification, (2) Fries rearrangement and (3) oxa-Michael ring closure.

TRPV1 ANTAGONISTS

Disclosed herein are compounds of formula (I), or pharmaceutically acceptable salts, solvates, prodrugs, salts of prodrugs, or combinations thereof, wherein R1, R2, R3, R4, and m are defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Antidiabetic and antiobesity effects of ampkinone (6f), a novel small molecule activator of AMP-activated protein kinase

Adenosine 5'-monophosphate (AMP) activated protein kinase (AMPK) has emerged as an attractive target molecule for the treatment of metabolic disorders, including obesity and type 2 diabetes. In this study, we identified a novel small molecule, ampkinone (