111491-30-6Relevant academic research and scientific papers
Creation of a monomeric vanadate species in an apatite framework as an active heterogeneous base catalyst for Michael reactions in water
Kaneda, Kiyotomi,Hara, Takayoshi,Hashimoto, Norifumi,Mitsudome, Takato,Mizugaki, Tomoo,Jitsukawa, Koichiro
, p. 93 - 98 (2010)
Vanadium-apatite containing the VO4 3- species was synthesized. Several characterization techniques such as XRD, TEM, XPS, ESR, UV-vis DRS, V K-edge XAFS, 51V MAS NMR, Raman spectroscopy, and CO2 TPD revealed th
Synthesis and biological evaluation of some new aryl pyrazol-3-one derivatives as potential hypoglycemic agents
Das, Nirupam,Verma, Abhilasha,Shrivastava, Prabhat K.,Shrivastava, Sushant K.
experimental part, p. 1555 - 1558 (2009/04/07)
Several new aryl substituted pyrazol-3-one 3 derivatives were prepared by the reaction of substituted phenyl hydrazine 1 with diethylethoxymethylene malonate (DEEM) 2. The compounds were synthesized by Michael addition reaction, which is a nucleophilic addition of enolate anions to the carbon-carbon double bond of α,β-unsaturated carboxylic acid derivatives. All the compounds were characterized by UV, IR and NMR spectroscopy and tested for hypoglycemic activity on alloxan induced diabetic rats. Among the tested compounds ethyl-2-para nitrophenyl-2,3-dihydro-1H-pyrazol-3-one-4-carboxylate 3c and ethyl-2-meta nitrophenyl-2,3-dihydro-1H-pyrazol-3-one-4-carboxylate 3d are identified as potent hypoglycemic agents and their activities are comparable with the standard drug metformin.
A direct preparation of 2-aryl-4-ethoxycarbonyl-3- pyrazolin-5-ones from aryl hydrazines
Taylor, Andrew W.,Cook, Richard T.
, p. 607 - 616 (2007/10/02)
Aryl hydrazines (1) possessing an electron-withdrawing substituent on the phenyl ring, on treatment with diethyl (ethoxymethylene)malonate in ethanolic sodium ethoxide solution, have directly afforded 2-aryl-4-ethoxy-carbonyl-3-pyrazolin-5-ones (4). Spect
