111492-60-5

Upstream product

• 5700-74-3 (S)-N-(ethoxycarbonyl)proline 
• 147-85-3 L-proline 

Downstream Products

• 1373153-97-9 C₃₉H₄₆N₂O₉ 
• 1373154-01-8 C₃₉H₄₆N₂O₉ 
• 1373153-98-0 C₃₈H₄₃ClN₂O₈ 
• 1373154-02-9 C₃₈H₄₃ClN₂O₈ 
• 1420453-39-9 C₂₅H₂₀BrNO₅ 
• 1373153-95-7 C₃₈H₄₄N₂O₈ 
• 1373153-99-1 C₃₈H₄₄N₂O₈ 
• 1373153-96-8 C₃₅H₄₆N₂O₈ 
• 1373154-00-7 C₃₅H₄₆N₂O₈ 
• 106202-17-9 ethyl (S)-2-benzoylpyrrolidine-1-carboxylate 
• 145057-61-0 N-ethoxycarbonyl-L-prolyl-(1-hydroxy)-cyclohexyl diazoethane 
• 145057-71-2 (N-ethoxycarbonyl-L-prolyl)-methyl-1-ene-2-phenyl-ethyl ketone 
• 145057-79-0 2-N-ethoxycarbonyl-L-prolyl-cyclohexanone 

Relevant academic research and scientific papers

ON-DEMAND PHOSPHORAMIDITE SYNTHESIS

The invention relates to a method of synthesis of phosphoramidites by immobilization of a phosphitylation agent on a resin activated to create a charged resin, then putting in contact with the charged resin with a suitable substrate. Phosphoramidites are synthesized in a few minutes from the application of the starting materials. Thus, the process makes it possible to create specific phosphoramidites on demand when they are needed in other applications. The substrates to be applied are mainly nucleosides, thus making it possible to create nucleoside phosphoramidites for the subsequent synthesis of oligonucleotides.

Stereocontrolled solid-phase synthesis of oligonucleoside H-phosphonates by an oxazaphospholidine approach

(Chemical Equation Presented) Stereodefined oligonucleoside H-phosphonates were synthesized on a solid support using diastereopure nucleoside 3′-O-oxazaphospholidine monomers. Several stereodefined backbone-modified analogues were obtained with the oligonucleoside H-phosphonates as precursors (see scheme; BPRO = protected nucleobase, DMTr = 4,4′- dimethoxytrityl, Th = thymin-1-yl, TfO- = triflate).

Synthesis and resolution of 2,2-dimethyl-1,3-diphenyl-1,3-propanediol, a new C2-symmetric and conformationally rigid acyclic diol

Diastereomerically pure (+)- and (-)-2,2-dimethyl-1,3-diphenyl-1,3-propanediols were synthesized starting from diethyl malonate and resolved through diesters of (-)-camphanic acid and also N-carbethoxy-L-proline. The absolute configuration of the (-)-enantiomer was established by X-ray crystallography.

Synthesis of Chiral N-Protected α-Amino-β-Diketones from α-Diazoketones Derived from Natural Amino Acids

α-Diazoketols, prepared by condensation of aldehydes or ketones with lithiated optically active α-diazoketones derived from natural amino acids, rearrange to homochiral α-amino-β-diketones on treatment with rhodium(II) acetate.