1114993-33-7Relevant academic research and scientific papers
Environmentally benign synthesis, molecular properties prediction and anti-inflammatory activity of novel isoxazolo[5,4-d]isoxazol-3-yl-aryl-methanones via vinylogous Henry nitroaldol adducts as synthons
Rajanarendar,Rama Krishna,Nagaraju,Govardhan Reddy,Kishore,Reddy
, p. 1630 - 1634 (2015)
Synthesis of novel 6-methylisoxazolo[5,4-d]isoxazol-3-yl-aryl-methanones 5 has been achieved via nitro-nitrite rearrangement by utilizing vinylogous nitroaldol adducts as synthons under mild conditions. Furthermore, the new series of compounds 5a-i were a
Difluoroisoxazolacetophenone: A Difluoroalkylation Reagent for Organocatalytic Vinylogous Nitroaldol Reactions of 1,2-Diketones
Zhang, Yong,Ge, Jin,Luo, Liang,Yan, Su-Qiong,Lai, Guo-Wei,Mei, Zu-Qin,Luo, Hai-Qing,Fan, Xiao-Lin
, p. 7952 - 7957 (2020)
Difluoroisoxazolacetophenone (DFIO) is developed as a new difluoroalkylation reagent that can be easily prepared from inexpensive starting materials. In situ remote C-C bond cleavage of DFIO affords γ,γ-difluoroisoxazole nitronate that undergoes base-catalyzed vinylogous nitroaldol additions to isatins, benzothiophene-2,3-dione, unsaturated-α-ketoesters, and cyclic 1,2-diketones. This organocatalytic debenzoate vinylogous nitroaldol reaction provides a new and mild approach for the preparation of various difluoroisoxazole-substituted 3-hydroxy-2-oxindoles.
'On water' direct vinylogous Henry (nitroaldol) reactions of 3,5-dimethyl-4-nitroisoxazole with aldehydes and trifluoromethyl ketones
Zhang, Yong,Wei, Biao-Wen,Zou, Li-Na,Kang, Mei-Lian,Luo, Hai-Qing,Fan, Xiao-Lin
, p. 2472 - 2475 (2016)
An efficient 'on water'-promoted direct catalytic vinylogous addition of 3,5-dimethyl-4-nitroisoxazole to aldehydes and trifluoromethyl ketones was described, giving Henry (nitroaldol) adducts in excellent yields. The trifluoromethyl tertiary alcohol prod
Vinylogous nitroaldol (Henry) reaction using 3,5-diethyl-4-nitroisoxazole and carbonyl compounds
Adamo, Mauro F.A.,Suresh, Surisetti
experimental part, p. 990 - 997 (2009/04/10)
3,5-Diethyl-4-nitroisoxazole reacted with carbonyl compounds in the presence of an amine catalyst. The vinylogous nitroaldol adducts were isolated in good yields.
