1115-22-6

Basic information

• Product Name: DIMETHYL ASPARTIC ACID
• Synonyms: DIMETHYL ASPARTIC ACID
• CAS NO: 1115-22-6
• Molecular Formula: C6H11NO4
• Molecular Weight: 161.15584
• Product Categories: Amino acids methyl、ethyl、t-butyl series
• Mol File: 1115-22-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 244.3°Cat760mmHg
• Flash Point: 101.6°C
• Appearance: /
• Density: 1.294g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: DIMETHYL ASPARTIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: DIMETHYL ASPARTIC ACID(1115-22-6)
• EPA Substance Registry System: DIMETHYL ASPARTIC ACID(1115-22-6)

Safety Data

• Hazardous Substances Data: 1115-22-6(Hazardous Substances Data)

Usage

General Description

Dimethyl aspartic acid is a chemical compound that is derived from aspartic acid, an amino acid found in many proteins. It is composed of two methyl groups attached to the aspartic acid molecule, hence the name dimethyl aspartic acid. This chemical has various industrial applications, including its use as a building block in the production of polymers and plastics. Additionally, it has been used in the formulation of certain cosmetics and personal care products. In the human body, dimethyl aspartic acid is involved in the metabolism of amino acids and the production of energy. Overall, this compound has a range of uses in both industrial and biological processes.

InChI:InChI=1/C6H11NO4/c1-7(2)4(6(10)11)3-5(8)9/h4H,3H2,1-2H3,(H,8,9)(H,10,11)

Upstream product

• 50-00-0 formaldehyd 
• 56-84-8 L-Aspartic acid 
• 4226-18-0 N-methyl-L-aspartic acid 
• 124-40-3 dimethyl amine 
• 110-17-8 (2E)-but-2-enedioic acid 

Relevant articles and documents

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Metal-catalyzed reductive deamination of glutamic acid to bio-based dimethyl glutarate and methylamines

Glutamic acid is a promising renewable platform molecule which is abundantly available in biomass waste streams; it is also efficiently manufactured by fermentation. Here we report the reductive deamination of glutamic acid to bio-based dimethyl glutarate and methylamines. In order to recycle nitrogen in an industrially relevant co-product, glutamic acid was modified to N,N-dimethylglutamic acid by a mild reductive alkylation with Pd/C. Subsequently, selective C-N hydrogenolysis in methanol resulted in dimethyl glutarate and trimethylamine. A wide screening of transition metals (Pt, Pd, Rh and Ru) immobilized on various supports showed that the highest yields of dimethyl glutarate were obtained with Pt/TiO2. An FTIR study and kinetic experiments on metal-loaded and unloaded supports demonstrate that the interplay between the metal and the moderate acidity of the support results in the excellent C-N hydrogenolysis activity and selectivity. Finally, reaction parameter optimization resulted in 81% yield of dimethyl glutarate with 1 wt% Pt/TiO2 at 225 °C, 30 bar H2 after 8 h.

Stable-isotope dimethylation labeling combined with LC-ESI MS for quantification of amine-containing metabolites in biological samples

One of the challenges associated with metabolome profiling in complex biological samples is to generate quantitative information on the metabolites of interest. In this work, a targeted metabolome analysis strategy is presented for the quantification of amine-containing metabolites. A dimethylation reaction is used to introduce a stable isotopic tag onto amine-containing metabolites followed by LC-ESI MS analysis. This labeling reaction employs a common reagent, formaldehyde, to label globally the amine groups through reductive animation. The performance of this strategy was investigated in the analysis of 20 amino acids and 15 amines by LC-ESI MS. It is shown that the labeling chemistry is simple, fast (13C-dimethylation does not show any isotope effect on either RPLC or HILIC LC, indicating that 13C-labeling is a preferred approach for relative quantification of amine-containing metabolites in different samples. The isotopically labeled 35 amine-containing analogues were found to be stable and proved to be effective in overcoming matrix effects in both relative and absolute quantification of these analytes present in a complicated sample, human urine. Finally, the characteristic mass difference provides additional structural information that reveals the existence of primary or secondary amine functional groups in amine-containing metabolites. As an example, for a human urine sample, a total of 438 pairs of different amine-containing metabolites were detected, at signal-to-noise ratios of greater than 10, by using the labeling strategy in conjunction with RP LC-ESI Fourier-transform ion cyclotron resonance MS.