111540-00-2

Usage

Uses

Used in Cancer Therapy:
STA 21 is used as an anticancer agent for its ability to inhibit cell proliferation, induce apoptosis, and suppress angiogenesis in cancer cells. Its mechanism of action involves antagonizing the mTORC1 signaling pathway, which plays a crucial role in cell growth and proliferation.
Used in Cardiovascular Disease Treatment:
STA 21 is used as a protective agent in cardiovascular disease for its observed protective effects on the heart in animal models. By targeting the mTORC1 pathway, it may help in managing or treating conditions associated with this disease.
Used in Neurodegenerative Disorders:
STA 21 is used as a neuroprotective agent in neurodegenerative disorders due to its protective effects on the brain observed in animal models. STA 21's action on the mTORC1 pathway may contribute to slowing down or managing the progression of these disorders.
Further research is ongoing to explore the full potential and mechanism of action of STA 21 in various disease settings, with the aim of expanding its applications and understanding its therapeutic benefits across different medical fields.

Upstream product

• 56630-78-5 (+/-)-rubiginone B₂ 
• 35023-83-7 3-ethoxy-5-methyl-cyclohex-2-enone 
• 51674-10-3 N,N-diethyl-2-methoxybenzamide 
• 96239-81-5 (1S,2S)-1-Hydroxy-8-methoxy-3-methyl-2-phenylselanyl-1,2,3,4-tetrahydro-benzo[a]anthracene-7,12-dione 
• 88790-44-7 3-formyl-5-methyl-2-cyclohexen-1-one 
• 70946-17-7 N,N-diethyl-2-formyl-6-methoxybenzamide 
• 96239-81-5 (1S,2S)-1-Hydroxy-8-methoxy-3-methyl-2-phenylselanyl-1,2,3,4-tetrahydro-benzo[a]anthracene-7,12-dione 
• 111539-99-2 8-Methoxy-3-methyl-2-phenylselanyl-3,4-dihydro-2H-benzo[a]anthracene-1,7,12-trione 
• 111539-90-3 N,N-Diethyl-2-[hydroxy-((6R,8R)-8-hydroxy-6-methyl-5,6,7,8-tetrahydro-naphthalen-1-yl)-methyl]-6-methoxy-benzamide 
• 111539-91-4 7-Methoxy-3-(6-methyl-5,6-dihydro-naphthalen-1-yl)-3H-isobenzofuran-1-one 
• 96239-80-4 2-Methoxy-6-(6-methyl-5,6-dihydro-naphthalen-1-ylmethyl)-benzoic acid 
• 96251-62-6 8-Methoxy-3-methyl-3,4-dihydro-benzo[a]anthracene-7,12-dione 
• 113457-99-1 (+/-)-3-ethynyl-5-methylcyclohex-2-enone 
• 4341-24-6 5-methylcyclohexan-1,3-dione 

Relevant academic research and scientific papers

Biosynthesis of PD 116740: Origins of the carbon, hydrogen, and oxygen atoms and derivation from a 6-deoxybenz[a]anthraquinone

The benz[a]anthraquinone antibiotic PD 116740 is formed from the regular cyclization of a decaketide intermediate folded in a manner to generate the angular tetracyclic skeleton. The 6-deoxybenz[a]anthraquinone tetrangulol is an intermediate, indicating t

Synthetic approaches to the angucycline antibiotics: the total syntheses of (+/-)-rubiginone B1 and B2, (+/-)-emycin A, and related analogues

The syntheses of the angucyclinone antibiotics; (+/-)-rubiginone B1 3 and B2 4, (+/-)-ochromycinone 7, and (+/-)-emycin A 12 are reported.The key step for the constructiuon of the benzoanthracene nucleus in each of the syntheses w

A NEW ROUTE FOR THE EFFICIENT SYNTHESIS OF (+/-)OCHROMYCINONE, A NATURALLY OCCURING BENZANTHRAQUINONE.

The Lewis acid-catalyzed cycloaddition of juglone 2 with dienes 3 led to the title compound.

Directed ortho metalation reactions. Convergent synthesis of "angular" anthracyclinones ochromycinone and X-14881 C

Convergent syntheses of the benzanthraquinone natural products X-14881 C (2c) and ochromycinone (2d) have been achieved using aromatic directed metalation strategies.Key steps involve (a) the condensations of dilithiated cis-tetralol (13a) with the ald

DIRECTED ORTHO METALATION REACTIONS. SYNTHESIS OF NATURALLY-OCCURRING BENZANTHRAQUINONES X-14881 C AND OCHROMYCINONE

The synthesis of the benzanthraquinone natural products X-14881 C (1c) and ochromycinone (1a) via an aromatic directed metalation strategy (Scheme 1) is described.