111559-41-2Relevant academic research and scientific papers
Design and optimization of hybrid of 2,4-diaminopyrimidine and arylthiazole scaffold as anticancer cell proliferation and migration agents
Zhou, Wenbo,Huang, Anling,Zhang, Yong,Lin, Qingxiang,Guo, Weikai,You, Zihua,Yi, Zhengfang,Liu, Mingyao,Chen, Yihua
, p. 269 - 280 (2015/04/27)
Therapeutics of metastatic or triple-negative breast cancer are still challenging in clinical. Herein we demonstrated the design and optimization of a series of hybrid of 2,4-diaminopyrimidine and arylthiazole derivatives for their anti-proliferative properties against two breast cancer cell lines (MCF-7 as human breast cancer and MDA-MB-231 as triple-negative breast cancer). More importantly, some of those compounds with potent antiproliferative activities also indicated excellent inhibitory activities against MDA-MB-231 cell migration. These results suggested that the new series of hybridation of aryl-thiazoles and aminopyrimidines could be identified and developed as novel highly potential anticancer agents against the triple-negative breast cancer as well as metastatic one in the future.
Dialkyl(2,3-Epoxy-4-oxoalkyl)phosphonates as Synthons for Thiazoles
Oehler, Elisabeth,Kang, Heun-Soo,Zbiral, Erich
, p. 533 - 546 (2007/10/02)
On reaction with thioureas and thioamides, the dialkyl (2,3-epoxy-4-oxoalkyl)phosphonates 6 can be transformed either into the new phosphonates 12 - 16, or to the (thiazolylvinyl)phosphonates 17 - 21.Cleavage of both system
