181424-15-7 Usage
Description
5-(BROMOMETHYL)-4-METHYL-2-PHENYL-1,3-THIAZOLE is a chemical compound with the molecular formula C11H10BrNS. It is a thiazole derivative featuring a bromomethyl group and a methyl-phenyl substitution. Thiazoles are heterocyclic organic compounds that contain both sulfur and nitrogen atoms in a five-membered ring structure. 5-(BROMOMETHYL)-4-METHYL-2-PHENYL-1,3-THIAZOLE may be utilized in organic synthesis, pharmaceutical research, or other chemical processes where the presence of a thiazole ring and a bromomethyl group are necessary. Due to its potential reactivity and toxicity, it is crucial to handle this compound with care.
Uses
Used in Organic Synthesis:
5-(BROMOMETHYL)-4-METHYL-2-PHENYL-1,3-THIAZOLE is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure, including the thiazole ring and bromomethyl group, allows for versatile chemical reactions and the formation of a wide range of compounds.
Used in Pharmaceutical Research:
In pharmaceutical research, 5-(BROMOMETHYL)-4-METHYL-2-PHENYL-1,3-THIAZOLE is used as a key intermediate in the development of new drugs. Its presence in a molecule can contribute to specific biological activities, making it a valuable component in the synthesis of potential therapeutic agents.
Used in Chemical Processes:
5-(BROMOMETHYL)-4-METHYL-2-PHENYL-1,3-THIAZOLE is also used in various chemical processes where its reactivity and functional groups are advantageous. The bromomethyl group can participate in a range of reactions, such as nucleophilic substitution, which can be harnessed to produce desired products in the chemical industry.
Used in Research and Development:
In research and development, 5-(BROMOMETHYL)-4-METHYL-2-PHENYL-1,3-THIAZOLE is utilized to explore new chemical reactions and mechanisms. Its unique properties can lead to the discovery of novel synthetic pathways and the development of innovative applications in various fields.
Used in Specialty Chemicals:
5-(BROMOMETHYL)-4-METHYL-2-PHENYL-1,3-THIAZOLE is used in the production of specialty chemicals that require the specific characteristics of thiazole derivatives. Its unique structure can impart particular properties to the final products, making it suitable for applications in coatings, dyes, or other specialized areas.
Check Digit Verification of cas no
The CAS Registry Mumber 181424-15-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,1,4,2 and 4 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 181424-15:
(8*1)+(7*8)+(6*1)+(5*4)+(4*2)+(3*4)+(2*1)+(1*5)=117
117 % 10 = 7
So 181424-15-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H10BrNS/c1-8-10(7-12)14-11(13-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3
181424-15-7Relevant articles and documents
Design, synthesis and biological evaluation of novel thiazole-derivatives as mitochondrial targeting inhibitors of cancer cells
Dang, Xin,Lei, Shuwen,Luo, Shuhua,Hu, Yixin,Wang, Juntao,Zhang, Dongdong,Lu, Dan,Jiang, Faqin,Fu, Lei
, (2021/06/16)
Mitochondria are pivotal energy production sources for cells to maintain necessary metabolism activities. Targeting dysfunctional mitochondrial features has been a hotspot for mitochondrial-related disease researches. Investigation with cancerous mitochondrial metabolism is a continuing concern within tumor therapy. Herein, we set out to assess the anti-cancer activities of a novel family of TPP-thiazole derivatives based on our earlier research on mitochondrial targeting agents. Specifically, we designed and synthesized a series of TPP-thiazole derivatives and revealed by the MTT assay that most synthesized compounds effectively inhibited three cancer cell lines (HeLa, PC3 and MCF-7). After structure modifications, we explored the SAR relationships and identified the most promising compound R13 (IC50 of 5.52 μM) for further investigation. In the meantime, we performed ATP production assay to assess the selected compounds inhibitory effect on HeLa cells energy production. The results displayed the test compounds significantly restrained ATP production of cancer cells. Overall, we have designed and synthesized a series of compounds which exhibited significant cytotoxicity against cancer cells and effectively inhibited mitochondrial energy production.
