111570-92-4

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 
• 184229-75-2 N-{9-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 

Downstream Products

• 173033-97-1 N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-methylsulfanylmethoxymethyl-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 250650-52-3 (2-{(2R,3S,5R)-5-(6-Benzoylamino-purin-9-yl)-3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-tetrahydro-furan-2-yl}-ethyl)-phosphonic acid mono-(4-methoxy-1-oxy-pyridin-2-ylmethyl) ester 
• 250650-36-3 4-Methoxy-1-oxido-2-picolyl phenyl[9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-6-N-benzoyladenin-6`-yl]phosphonate 
• 250650-18-1 Diphenyl-[9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hexofuranosyl)-6-N-benzoyladenin-6`-yl]phosphonate 
• 250650-03-4 Diphenyl-[9-(3`-O-tert-butyldiphenylsilyl-2`,5`,6`-trideoxy-β-D-erythro-hex-5-enofuranosyl)-6-N-benzoyladenin-6`-yl]phosphonate 
• 514211-10-0 1-(3-O-tert-butyldiphenylsilyl-2,5-dideoxy-β-D-glycero-pent-4-enofuranosyl)adenine 
• 942195-27-9 5'-bromo-3'-O-tert-butyldiphenylsilyl-2',5'-dideoxyadenosine 

Relevant academic research and scientific papers

NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSHOROUS (V) COMPOUNDS

The present invention relates to novel phosphorous (V) (P(V)) reagents, methods for preparing thereof, and methods for preparing organophosphorous (V) compounds by using the novel reagents.

Alteration of DNA primary structure by DNA topoisomerase I. Isolation of the covalent topoisomerase I-DNA binary complex in enzymatically competent form

DNA ligation by DNA topoisomerase I was investigated employing synthetic DNA substrates containing a single strand nick. Site-specific cleavage of the DNA by topoisomerase I in proximity to the nick resulted in uncoupling of the cleavage and ligation reac