184229-75-2

Upstream product

• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 59921-48-1 N-benzoyltetrazole 
• 98-88-4 benzoyl chloride 

Downstream Products

• 111570-92-4 N⁶-benzoyl-3'-O-(tert-butyldiphenylsilyl)-2'-deoxyadenosine 
• 184229-78-5 N-{9-[(2R,4S,5R)-5-Aminomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 125443-94-9 N-{9-[(2R,4S,5R)-4-Hydroxy-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 184229-77-4 N-{9-[(2R,4S,5R)-5-Azidomethyl-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 
• 184229-76-3 Toluene-4-sulfonic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-3-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-ylmethyl ester 
• 184229-79-6 N-{9-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide 

Relevant academic research and scientific papers

A mild and highly selective N-benzoylation of cytosine and adenine bases in mucleosides with N-benzoyltetrazole

N-Benzoyltetrazole has been developed as a mild and selective reagent for monobenzoylation of the exocyclic amino group in nucleic acid bases. Its usefulness is demonstrated by protection of adenine and cytosine bases, an important procedure in the nucleic acid chemistry field.

Alteration of DNA primary structure by DNA topoisomerase I. Isolation of the covalent topoisomerase I-DNA binary complex in enzymatically competent form

DNA ligation by DNA topoisomerase I was investigated employing synthetic DNA substrates containing a single strand nick. Site-specific cleavage of the DNA by topoisomerase I in proximity to the nick resulted in uncoupling of the cleavage and ligation reac