1115951-84-2

Upstream product

• 951163-93-2 α,α-dibromo-2'-bromoacetophenone 
• 124-40-3 dimethyl amine 
• 2142-69-0 2-bromophenyl methyl ketone 
• 68-12-2 N,N-dimethyl-formamide 
• 26767-16-8 2-(2-bromophenyl)-2-oxoacetic acid 
• 1973-22-4 1-bromo-2-ethylbenzene 
• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 159749-30-1 1-(2-bromophenyl)-3-(dimethylamino)-2-propen-1-one 

Relevant academic research and scientific papers

Metal-Free C=C Double Bond Cleavage on Enaminones for the Synthesis of α-Ketoamides by Free-Radical Aerobic Oxygenation

The tandem oxidation of the enaminone C=C double bond as well as subsequent C-N bond formation are realized under metal-free conditions by thermo-induced free radical transformation. In the presence of benzoyl peroxide (BPO) and N-iodosuccinimide (NIS), a

Transition metal-free synthesis of α-ketoamides from arylmethyl ketones and alkylphosphoramides

A transition metal-free protocol has been developed for the synthesis of α-ketoamides from aryl methyl ketones and alkylphosphoramides in the presence of oxidant, aqueous tert-butyl hydroperoxide (TBHP). A series of aryl methyl ketones having both electron-donating as well as electron-withdrawing groups were successfully employed for the synthesis of their corresponding α-ketoamides using hexamethylphosphoramide and other alkylphosphoramides.

The syntheses of α-ketoamides vianBu4NI- catalyzed multiple sp3C-H bond oxidation of ethylarenes and sequential coupling with dialkylformamides

The nBu4NI-catalyzed sequential C-O and C-N bond formation via multiple sp3C-H bond activation of ethylarenes, using N,N-dialkylformamide as the amino source, provided α-ketoamides with moderate yields. This journal is

Synthesis of α-ketoamides from Aryl methyl ketones and N, N -dimethylformamide via copper-catalyzed aerobic oxidative coupling

A copper-catalyzed aerobic oxidative coupling of aryl methyl ketones with N,N-dimethylformamide was developed, which afforded α-ketoamides by a sequence of dioxygen activation, C-H bond functionalization, and amide formation with N,N-dimethylformamide as

Cu(ii)-catalyzed decarboxylative acylation of acyl C-H of formamides with α-oxocarboxylic acids leading to α-ketoamides

CuBr2-catalyzed decarboxylative acylation of the acyl C-H of N-monosubstituted and N,N-disubstituted formamides with α-oxocarboxylic acids leading to α-ketoamides was developed, which generated the corresponding products in good yields. The Royal Society of Chemistry 2013.

Direct use of formamides as amino group sources via C-N bond cleavage: A catalytic oxidative synthesis of α-ketoamides from acetophenones and formamides under metal-free conditions

An efficient and direct use of formamides as amino group sources for the synthesis of α-ketoamides was developed under metal-free conditions. The reaction was based on the oxidative coupling of acetophenones with formamides and generated the desired products in good yields in the presence of t-BuOOH/I2/PhCO2H.

Aerial oxidation of 2,2-dibromo-1-aryl and heteroaryl ethanones: A facile synthesis of aryl and heteroaryl α-keto amides

The aerial oxidation of various 2,2-dibromo-1-aryl and heteroaryl ethanones to α-keto amides in the presence of air or oxygen and secondary amines are described. The reaction provides α-keto amides in moderate to good yields. The versatility of the reacti