111601-07-1

Upstream product

• 75841-61-1 (E)-4⁽⁵⁾-(2-phenylethenyl)imidazole 
• 80-48-8 methyl p-toluene sulfonate 
• 100-42-5 styrene 
• 71759-87-0 4-iodo-1-methyl-1H-imidazole 

Relevant academic research and scientific papers

Novel synthesis of 4(5)-monosubstituted imidazoles via cycloaddition of tosylmethyl isocyanide to aldimines

4(5)-Monosubstituted imidazoles (9) have been prepared via base-induced cycloaddition of tosylmethyl isocyanide (TosMIC) to N-(dimethylsulfamoyl)aldimines (2) or N-tosylaldimines (3). In the first case, N-(dimethylsulfamoyl)imidazoles 8 are the initial reaction products, from which the dimethylsulfamoyl group is readily removed with aqueous HBr. In the second case, the tosyl group of 1-tosylimidazoles 10 is lost spontaneously to give 4(5)-monosubstituted imidazoles 9 in one operation.

Palladium-Catalyzed Reactions of Terminal Acetylenes and Olefins with Halo-1,3-azoles

The palladium-catalyzed reactions of 4-bromo- and 5-bromothiazoles, as well as 4-bromo and 5-bromooxazoles with terminal acetylenes gave ethynyl derivatives in 43-89percent yields, whereas the reactions of 2-bromothiazoles and iodo-N-methylimidazoles affo