1116231-38-9Relevant academic research and scientific papers
Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity
Chamberlain, Stanley D.,Redman, Aniko M.,Wilson, Joseph W.,Deanda, Felix,Shotwell, J. Brad,Gerding, Roseanne,Lei, Huangshu,Yang, Bin,Stevens, Kirk L.,Hassell, Anne M.,Shewchuk, Lisa M.,Leesnitzer, M. Anthony,Smith, Jeffery L.,Sabbatini, Peter,Atkins, Charity,Groy, Arthur,Rowand, Jason L.,Kumar, Rakesh,Mook Jr., Robert A.,Moorthy, Ganesh,Patnaik, Samarjit
, p. 360 - 364 (2009)
The SAR of C5′ functional groups with terminal basic amines at the C6 aniline of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines is reported. Examples demonstrate potent inhibition of IGF-1R with 1000-fold selectivity over JNK1 and 3 in enzymatic assays.
