111634-90-3Relevant articles and documents
A short, efficient synthesis of substituted uracil: An indane carbocyclic nucleoside
Ferna?ndez,Garci?a-Mera,Morales,Rodri?guez-Borges
, p. 239 - 242 (2001)
(±)-cis-1-(3-Hydroxymethyl-1-indanyl)-1,2,3,4-tetrahy-dropyrimidine-2, 4-dione (1) was synthesised in two steps and with an overall yield of 51percent from (±)-cis-3-amino-1-indanylmethanol (4) and 3-ethoxy-2-propenoyl isocyanate (3). The isocyanate 3 was prepared in 76percent overall yield by reacting silver cyanate with 3-ethoxy-2-propenoyl chloride (2), which was obtained in one pot from ethyl vinyl ether and oxalyl chloride. The aminoalcohol (4) was prepared from phenylsuccinic anhydride in four steps.
Conformational and steric aspects of the inhibition of phenylethanolamine N-methyltransferase by benzylamines
Grunewald,Sall,Monn
, p. 433 - 444 (2007/10/02)
Compounds of the benzylamine (BA) class are potent inhibitors of phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28). Restriction of the aminomethyl side chain through its incorporation into a cyclic framework as in 1,2,3,4-tetrahydroisoquinoline (
