111648-85-2

Upstream product

• 100-52-7 benzaldehyde 
• 111633-25-1 O-benzyl-N-carbobenzoxy-2,6-dimethyl-DL-tyrosine 
• 71-55-6 1,1,1-trichloroethane 
• 111633-23-9 N-Z-2,6-dimethyl-DL-tyrosine benzyl ester 
• 112244-89-0 N-carbobenzoxy-2,6-dimethyl-DL-tyrosine 
• 501-53-1 benzyl chloroformate 
• 111633-24-0 O-benzyl-N-carbobenzoxy-2,6-dimethyl-DL-tyrosine benzyl ester 
• 80110-73-2 2,6-dimethyltyrosine hydrochloride 

Downstream Products

• 111648-86-3 benzyl 4-<<2,6-dimethyl-4-(phenylmethoxy)phenyl>-methyl>-4-methyl-5-oxo-2-phenyl-3-oxazolidinecarboxylate 
• 111648-88-5 α,2,6-trimethyl-N-<(phenylmethoxy)carbonyl>-O-(phenylmethyl)-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide 
• 111633-26-2 α,2,6,-trimethyl-N-<(phenylmethoxy)carbonyl>-O-(phenylmethyl)-D-tyrosyl-N-(3-phenylpropyl)-D-alaninamide 
• 111648-87-4 α,2,6-trimethyl-4-(phenylmethoxy)-α-<<(phenylmethoxy)carbonyl>amino>benzenepropionic acid 

Relevant academic research and scientific papers

Enkephalin analogs as systemically active antinociceptive agents: O- and N-alkylated derivatives of the dipeptide amide L-2,6-dimethyltyrosyl-N-(3- phenylpropyl)-D-alaninamide

A number of O- and N-alkylated derivatives of the antinociceptive, orally active, μ-opioid-selective truncated enkephalin analog L-2,6- dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide (2,SC-39566) were synthesized to explore the structure-activity relati

N-terminally substituted dipeptide amides

This invention encompasses compounds of the formula STR1 and the pharmaceutically acceptable acid addition salts thereof wherein R1 is lower alkoxy or --O--(CH2)n -phenyl where the phenyl may be optionally substituted with halogen, --NO2, --CN, --NH2 or lower alkyl wherein n is 1 to 4; R2 and R3 represent lower alkyl, halogen, lower alkoxy or one of R2 or R3 is hydrogen and the other is lower alkyl, lower alkoxy, or halogen; R4, R5, R7, R8, and R9 represent hydrogen or lower alkyl, R6 represents hydrogen, lower alkyl, lower alkenyl, or --(CH2)m -cycloalkyl wherein m is 1 to 4 and the cycloalkyl has 3 to 8 carbon atoms; R10 is --(CH2)p -phenyl wherein p is 1 to 4; and v represents an asymmetric carbon that may be racemic or have the D or L Configuration; w represents an asymmetric carbon when R7 and R8 are not the same that may be racemic or have the D or L configuration. This invention also encompasses compounds where R1 is hydroxy, provided at least one of R4, R5, R6 or R9 is lower alkyl. The compounds of this invention are useful analgesic agents.