1117-23-3

Basic information

• Product Name: 3-AMino-1,5-pentanediol
• Synonyms: 3-AMino-1,5-pentanediol
• CAS NO: 1117-23-3
• Molecular Formula: C₅H₁₃NO₂
• Molecular Weight: 119.16222
• Mol File: 1117-23-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Methanol
• CAS DataBase Reference: 3-AMino-1,5-pentanediol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMino-1,5-pentanediol(1117-23-3)
• EPA Substance Registry System: 3-AMino-1,5-pentanediol(1117-23-3)

Safety Data

• Hazardous Substances Data: 1117-23-3(Hazardous Substances Data)

Usage

Uses

3-Amino-1,5-pentanediol is an substituent in the synthesis of Pamapimod (P167500), a selective inhibitor of the α-isoform of p38 MAP kinase.

Upstream product

• 51865-85-1 1,3-diethyl 2-aminoglutarate 
• 77313-09-8 3-aminoglutaric acid dimethyl ester 
• 82803-55-2 3-tert-butoxycarbonylaminopentanedioic acid dimethyl ester 
• 63547-62-6 dimethyl 3-aminoglutaconate 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 1092775-83-1 tert-butyl N-[3-hydroxy-1-(2-hydroxyethyl)propyl]carbamate 
• 1034082-96-6 2-(N-benzylamino)pentane-1,5-diol 
• 2049-67-4 diethyl glutaconate 

Downstream Products

• 1092457-58-3 C₁₉H₂₀F₃IN₄O₄ 
• 449811-01-2 [14C]-Pamapimod 

Relevant articles and documents

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR

The present disclosure provides pyrimidine compounds and uses thereof, for example, for the treatment of diseases associated with P2X purinergic receptors. In certain aspects, the present disclosure provides P2X3 and/or P2X2/3 antagonists which are useful, for example, for the treatment of visceral organ, cardiovascular and pain-related diseases, conditions and disorders.

Scalable non-aqueous process to prepare water soluble 3-amino-pentan-1,5- diol

The development of a nonaqueous process for the synthesis of 3-amino-pentan-1,5-diol is described. Beginning with dimethyl acetone-1,3-dicarboxylate, a telescoped sequence of reductive amination, Boc protection, sodium borohydride reduction, and acidic resin-mediated deprotection generates the title compound. The key to this efficient process is the telescoped deprotection, purification and nonaqueous isolation of the 3-amino-pentan-1,5- diol. The process involves four optimized chemical reactions using two solvents in 89% overall yield and 97-98 area % purity.