63547-62-6

Basic information

• Product Name: dimethyl 3-aminopent-2-enedioate
• CAS NO: 63547-62-6
• Molecular Formula: C₇H₁₁NO₄
• Molecular Weight: 173.1665
• Mol File: 63547-62-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 286°C at 760 mmHg
• Flash Point: 140.2°C
• Density: 1.168g/cm³
• Vapor Pressure: 0.0027mmHg at 25°C
• Refractive Index: 1.471
• CAS DataBase Reference: dimethyl 3-aminopent-2-enedioate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 3-aminopent-2-enedioate(63547-62-6)
• EPA Substance Registry System: dimethyl 3-aminopent-2-enedioate(63547-62-6)

Safety Data

• Hazardous Substances Data: 63547-62-6(Hazardous Substances Data)

Usage

General Description

Dimethyl 3-aminopent-2-enedioate, also known as dimethyl 2-amino-3-methyl-2-butenedioate, is a chemical compound with the molecular formula C7H11NO4. It is a derivative of malic acid and is commonly used as a chelating agent in the food and pharmaceutical industries. dimethyl 3-aminopent-2-enedioate is also utilized in the synthesis of various pharmaceutical drugs and organic compounds due to its ability to form stable complexes with metal ions. Additionally, dimethyl 3-aminopent-2-enedioate has applications in the field of chemistry research, particularly in the study of coordination chemistry and metal-ligand interactions. Overall, this chemical compound plays a crucial role in various industrial and scientific applications.

Upstream product

• 1830-54-2 3-oxopentanedioic acid dimethyl ester 

Downstream Products

• 82803-55-2 3-tert-butoxycarbonylaminopentanedioic acid dimethyl ester 
• 1117-23-3 3-aminopentane-1,5-diol 

Relevant articles and documents

Scalable non-aqueous process to prepare water soluble 3-amino-pentan-1,5- diol

The development of a nonaqueous process for the synthesis of 3-amino-pentan-1,5-diol is described. Beginning with dimethyl acetone-1,3-dicarboxylate, a telescoped sequence of reductive amination, Boc protection, sodium borohydride reduction, and acidic resin-mediated deprotection generates the title compound. The key to this efficient process is the telescoped deprotection, purification and nonaqueous isolation of the 3-amino-pentan-1,5- diol. The process involves four optimized chemical reactions using two solvents in 89% overall yield and 97-98 area % purity.

NOVEL PROCESS FOR THE PREPARATION OF 3-AMINO-PENTAN-1,5-DIOL

The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-1,5-diol (2), which is useful for the preparation of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one (1) a MAP-kinase inhibitor useful in the treatment of rheumatoid arthritis.