63547-62-6

Usage

Uses

Used in Food Industry:
Dimethyl 3-aminopent-2-enedioate is used as a chelating agent to bind metal ions, which helps to prevent oxidation and spoilage of food products, thereby extending their shelf life.
Used in Pharmaceutical Industry:
Dimethyl 3-aminopent-2-enedioate is used as a chelating agent in the formulation of pharmaceutical drugs, enhancing their stability and bioavailability.
Used in Chemical Research:
Dimethyl 3-aminopent-2-enedioate is used as a ligand in coordination chemistry, enabling the study of metal-ligand interactions and the development of new compounds with potential applications in various fields.
Used in Synthesis of Pharmaceutical Drugs:
Dimethyl 3-aminopent-2-enedioate is used as a key intermediate in the synthesis of various pharmaceutical drugs, contributing to the development of new medications with improved therapeutic properties.

Upstream product

• 1830-54-2 3-oxopentanedioic acid dimethyl ester 

Downstream Products

• 82803-55-2 3-tert-butoxycarbonylaminopentanedioic acid dimethyl ester 
• 1117-23-3 3-aminopentane-1,5-diol 

Relevant academic research and scientific papers

Scalable non-aqueous process to prepare water soluble 3-amino-pentan-1,5- diol

The development of a nonaqueous process for the synthesis of 3-amino-pentan-1,5-diol is described. Beginning with dimethyl acetone-1,3-dicarboxylate, a telescoped sequence of reductive amination, Boc protection, sodium borohydride reduction, and acidic resin-mediated deprotection generates the title compound. The key to this efficient process is the telescoped deprotection, purification and nonaqueous isolation of the 3-amino-pentan-1,5- diol. The process involves four optimized chemical reactions using two solvents in 89% overall yield and 97-98 area % purity.

PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR

The present disclosure provides pyrimidine compounds and uses thereof, for example, for the treatment of diseases associated with P2X purinergic receptors. In certain aspects, the present disclosure provides P2X3 and/or P2X2/3 antagonists which are useful, for example, for the treatment of visceral organ, cardiovascular and pain-related diseases, conditions and disorders.

NOVEL PROCESS FOR THE PREPARATION OF 3-AMINO-PENTAN-1,5-DIOL

The present invention provides a novel method for preparing a key intermediate, 3-amino-pentan-1,5-diol (2), which is useful for the preparation of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one (1) a MAP-kinase inhibitor useful in the treatment of rheumatoid arthritis.

PYRIDINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV

A compound represented by the formula wherein R1 and R2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted hydroxy group; R3 is an optionally substituted aromatic group; R4 is an optionally substituted amino group; L is a divalent chain hydrocarbon group; Q is a bond or a divalent chain hydrocarbon group; and X is a hydrogen atom, a cyano group, a nitro group, an acyl group, a substituted hydroxy group, an optionally substituted thiol group, an optionally substituted amino group or an optionally substituted cyclic group; provided that when X is an ethoxycarbonyl group, then Q is a divalent chain hydrocarbon group. The compound has a peptidase inhibitory action, is useful as an agent for the prophylaxis or treatment of diabetes and the like, and is superior in efficacy, duration of action, specificity, lower toxicity and the like.