111787-83-8

Basic information

• Product Name: ETHYL 5-(4-FLUOROPHENYL)-2-METHYL-3-FUROATE
• Synonyms: ETHYL 5-(4-FLUOROPHENYL)-2-METHYL-3-FUROATE;5-(4-Fluoro-phenyl)-2-methyl-furan-3-carboxylic acid ethyl ester
• CAS NO: 111787-83-8
• Molecular Formula: C₁₄H₁₃FO₃
• Molecular Weight: 248.25
• Mol File: 111787-83-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 154 °C
• Flash Point: 152.9°C
• Appearance: /
• Density: 1.168g/cm³
• Vapor Pressure: 0.000181mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: ETHYL 5-(4-FLUOROPHENYL)-2-METHYL-3-FUROATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-(4-FLUOROPHENYL)-2-METHYL-3-FUROATE(111787-83-8)
• EPA Substance Registry System: ETHYL 5-(4-FLUOROPHENYL)-2-METHYL-3-FUROATE(111787-83-8)

Safety Data

• Hazardous Substances Data: 111787-83-8(Hazardous Substances Data)

Usage

General Description

ETHYL 5-(4-FLUOROPHENYL)-2-METHYL-3-FUROATE is a chemical compound with a molecular formula of C14H13FO3. It is a furoate ester that contains a 4-fluorophenyl group and a methyl group attached to the furoate core. ETHYL 5-(4-FLUOROPHENYL)-2-METHYL-3-FUROATE is used in organic synthesis and pharmaceutical research as a building block for the synthesis of other chemical compounds. It has potential applications in the development of drugs and other biologically active molecules due to its unique structural features and properties. However, it is important to handle and use this compound with caution as it may have potential health and environmental hazards.

InChI:InChI=1/C14H13FO3/c1-3-17-14(16)12-8-13(18-9(12)2)10-4-6-11(15)7-5-10/h4-8H,3H2,1-2H3

Upstream product

• 141-97-9 ethyl acetoacetate 
• 159957-00-3 1-(2,2-dibromovinyl)-4-fluorobenzene 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 75230-49-8 N′-(1-(4-fluorophenyl)ethylidene)-4-methylbenzenesulfonohydrazide 
• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 
• 58518-77-7 ((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane 
• 766-98-3 1-ethynyl-4-fluorobenzene 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 36967-50-7 ethyl 2-acetyl-4-(4-fluorophenyl)-4-oxobutanoate 

Downstream Products

• 111787-88-3 5-(4-fluorophenyl)-2-methyl-3-furancarboxylic acid 
• 111787-93-0 [5-(4-fluorophenyl)-2-methyl-furan-3-yl]methanol 

Relevant articles and documents

Tuning radical reactivity using iodine in oxidative C(sp3)-H/C(sp)-H cross-coupling: An easy way toward the synthesis of furans and indolizines

Molecular iodine was found to be an effective redox catalyst for the oxidative cross-coupling of carbonyl compounds with terminal alkynes. In this work, we demonstrated that iodine could tune radical reactivity through reversible C-I bond formation for co

Copper-Mediated [3 + 2] Oxidative Cyclization Reaction of N-Tosylhydrazones and β-Ketoesters: Synthesis of 2,3,5-Trisubstituted Furans

The first attempt at utilizing N-tosylhydrazones as two-carbon synthons has been successfully achieved, which underwent a copper-mediated [3 + 2] oxidative cyclization reaction to afford 2,3,5-trisubstituted furans in moderate to good yields. The features of this method include inexpensive metal catalyst, readily available substrates, high regioselectivity, and convenient operation. The studies provide important approaches for further exploration of the powerful and diverse reaction abilities of N-tosylhydrazones.

Cu(I)-catalyzed reaction of diazo compounds with terminal alkynes: A direct synthesis of trisubstituted furans

A method for the synthesis of tri-substituted furans has been developed based on Cu(I)-catalyzed reaction of terminal alkynes with β-keto α-diazoesters. This method for the synthesis of 2,3,5-trisubstituted furans is operationally simple and applicable to