111787-83-8

Usage

Uses

Used in Organic Synthesis:
ETHYL 5-(4-FLUOROPHENYL)-2-METHYL-3-FUROATE is used as a building block in organic synthesis for the creation of other chemical compounds. Its unique structure allows for the development of a variety of molecules with potential applications across different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, ETHYL 5-(4-FLUOROPHENYL)-2-METHYL-3-FUROATE is utilized as a precursor in the synthesis of drugs and other biologically active molecules. Its structural attributes contribute to the design of new therapeutic agents, potentially leading to advancements in medicinal chemistry.
It is crucial to handle ETHYL 5-(4-FLUOROPHENYL)-2-METHYL-3-FUROATE with care due to its potential health and environmental hazards, ensuring safe practices in research and development settings.

InChI:InChI=1/C14H13FO3/c1-3-17-14(16)12-8-13(18-9(12)2)10-4-6-11(15)7-5-10/h4-8H,3H2,1-2H3

Upstream product

• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 
• 58518-77-7 ((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 141-97-9 ethyl acetoacetate 
• 36967-50-7 ethyl 2-acetyl-4-(4-fluorophenyl)-4-oxobutanoate 
• 159957-00-3 1-(2,2-dibromovinyl)-4-fluorobenzene 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 75230-49-8 N′-(1-(4-fluorophenyl)ethylidene)-4-methylbenzenesulfonohydrazide 
• 766-98-3 1-ethynyl-4-fluorobenzene 

Downstream Products

• 111787-88-3 5-(4-fluorophenyl)-2-methyl-3-furancarboxylic acid 
• 111787-93-0 [5-(4-fluorophenyl)-2-methyl-furan-3-yl]methanol 

Relevant academic research and scientific papers

Tuning radical reactivity using iodine in oxidative C(sp3)-H/C(sp)-H cross-coupling: An easy way toward the synthesis of furans and indolizines

Molecular iodine was found to be an effective redox catalyst for the oxidative cross-coupling of carbonyl compounds with terminal alkynes. In this work, we demonstrated that iodine could tune radical reactivity through reversible C-I bond formation for co

Synthesis of polysubstituted furans from aryl gem-dibromoethenes

[Figure not available: see fulltext.] Synthesis of 2,3,5-trisubstituted furans can be performed at 120°C in DMF using aryl gem-dibromoethenes and ethyl acetoacetate as the starting substrates under the assistance of Ag2CO3–Cs2/

Copper-Mediated [3 + 2] Oxidative Cyclization Reaction of N-Tosylhydrazones and β-Ketoesters: Synthesis of 2,3,5-Trisubstituted Furans

The first attempt at utilizing N-tosylhydrazones as two-carbon synthons has been successfully achieved, which underwent a copper-mediated [3 + 2] oxidative cyclization reaction to afford 2,3,5-trisubstituted furans in moderate to good yields. The features of this method include inexpensive metal catalyst, readily available substrates, high regioselectivity, and convenient operation. The studies provide important approaches for further exploration of the powerful and diverse reaction abilities of N-tosylhydrazones.

Copper-Catalyzed Coupling of 2-Siloxy-1-alkenes and Diazocarbonyl Compounds: Approach to Multisubstituted Furans, Pyrroles, and Thiophenes

We report herein copper(II)-catalyzed cyclization reactions of silyl enol ethers derived from methyl ketones with α-diazo-β-ketoesters or α-diazoketones to afford 2-siloxy-2,3-dihydrofuran derivatives or 2,3,5-trisubstituted furans, respectively, under mild conditions. The former cyclization products serve as versatile 1,4-diketone surrogates, allowing facile preparation of 2,3,5-trisubstituted furans, pyrroles, and thiophenes.

Cu(I)-catalyzed reaction of diazo compounds with terminal alkynes: A direct synthesis of trisubstituted furans

A method for the synthesis of tri-substituted furans has been developed based on Cu(I)-catalyzed reaction of terminal alkynes with β-keto α-diazoesters. This method for the synthesis of 2,3,5-trisubstituted furans is operationally simple and applicable to

Silver-mediated oxidative C-H/C-H functionalization: A strategy to construct polysubstituted furans

A novel silver-mediated highly selective oxidative C-H/C-H functionalization of 1,3-dicarbonyl compounds with terminal alkynes for the creation of polysubstituted furans and pyrroles in one step has been demonstrated. Promoted by the crucial silver specie