111808-94-7

Usage

Chemical structure

Furan derivative with a chlorophenyl group and a hydroxymethyl group attached to the furan ring, with a methyl group at the 2-position

Pharmacological properties

Studied for potential anti-inflammatory and antimicrobial activities

Pharmacological properties

Anti-inflammatory
Antimicrobial

Industrial uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Safety considerations

Handle with care due to potential health and environmental hazards

Chemical compound

5-(4-Chlorophenyl)-3-hydroxymethyl-2-methylfuran

Main properties

Furan derivative
Chlorophenyl group attached
Hydroxymethyl group attached
Methyl group at the 2-position

Uses

Intermediate in the synthesis of pharmaceuticals
Intermediate in the synthesis of agrochemicals

Hazards

Health hazards
Environmental hazards

Caution

Handle with care

Upstream product

• 536-38-9 4-chlorobenzoylmethyl bromide 
• 111787-82-7 2-[2-(4-chlorophenyl)-2-oxo-ethyl]-3-oxo-butyric acid ethyl ester 
• 111787-89-4 2-methyl-5-(4-chlorophenyl)-furan-3-carboxylic acid 
• 111787-84-9 ethyl 5-(4-chlorophenyl)-2-methylfuran-3-carboxylate 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND

The present invention provides a heterocyclic compound represented by the following formula (I), which has a glucagon antagonistic action and is useful for the prophylaxis or treatment of diabetes and the like, a compound represented by wherein ring A is an optionally substituted benzene ring and the like; Y is a nitrogen atom and the like; X is -O- and the like; R4 is a hydrogen atom and the like; R5 and R6 are each independently a hydrogen atom and the like; R1 is an optionally substituted hydrocarbon group and the like; R2 is a hydrogen atom and the like; and R3 is -(CH2)3-COOH and the like, or a salt thereof.

HETEROCYCLIC GPR40 MODULATORS

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

FURAN OR THIOPHENE DERIVATIVE AND MEDICINAL USE THEREOF

The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R1 is a hydrogen atom or an optionally substituted hydrocarbon group, R2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X1 is an oxygen atom or a sulfur atom, X2 is a bond, an oxygen atom or -S(O)n- (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, -S(O)m-, -C(=O)-N(R3)- or -N(R3)-C(=O)- (R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M1, M2 and M3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M4 is an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.