111787-84-9

Upstream product

• 99-91-2 para-chloroacetophenone 
• 873-73-4 4-n-chlorophenylacetylene 
• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 
• 141-97-9 ethyl acetoacetate 
• 77295-59-1 1-chloro-4-(2,2-dibromovinyl)benzene 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 75-03-6 ethyl iodide 
• 111787-89-4 2-methyl-5-(4-chlorophenyl)-furan-3-carboxylic acid 
• 111787-82-7 2-[2-(4-chlorophenyl)-2-oxo-ethyl]-3-oxo-butyric acid ethyl ester 
• 75230-50-1 p-chloroacetophenone tosylhydrazone 
• 1956-39-4 4-chloroacetophenone oxime 
• 208118-80-3 1-(4-chlorophenyl)ethenylacetamide 

Downstream Products

• 111808-94-7 [5-(4-Chlorophenyl)-2-methyl-furan-3-yl]methanol 
• 111787-89-4 2-methyl-5-(4-chlorophenyl)-furan-3-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of polysubstituted furans from aryl gem-dibromoethenes

[Figure not available: see fulltext.] Synthesis of 2,3,5-trisubstituted furans can be performed at 120°C in DMF using aryl gem-dibromoethenes and ethyl acetoacetate as the starting substrates under the assistance of Ag2CO3–Cs2/

Copper-Mediated [3 + 2] Oxidative Cyclization Reaction of N-Tosylhydrazones and β-Ketoesters: Synthesis of 2,3,5-Trisubstituted Furans

The first attempt at utilizing N-tosylhydrazones as two-carbon synthons has been successfully achieved, which underwent a copper-mediated [3 + 2] oxidative cyclization reaction to afford 2,3,5-trisubstituted furans in moderate to good yields. The features of this method include inexpensive metal catalyst, readily available substrates, high regioselectivity, and convenient operation. The studies provide important approaches for further exploration of the powerful and diverse reaction abilities of N-tosylhydrazones.

Tuning radical reactivity using iodine in oxidative C(sp3)-H/C(sp)-H cross-coupling: An easy way toward the synthesis of furans and indolizines

Molecular iodine was found to be an effective redox catalyst for the oxidative cross-coupling of carbonyl compounds with terminal alkynes. In this work, we demonstrated that iodine could tune radical reactivity through reversible C-I bond formation for co

Direct oxidative coupling of enamides and 1,3-dicarbonyl compounds: A facile and versatile approach to dihydrofurans, furans, pyrroles, and dicarbonyl enamides

An efficient manganese(III)-mediated oxidative coupling reaction between α-aryl enamides and 1,3-dicarbonyl compounds has been developed. A series of dihydrofurans and dicarbonyl enamides were synthesized in moderate to good yields. Moreover, these dihydrofurans could be readily transformed into the corresponding furans and pyrroles via the Paal-Knorr reaction.

Cu(I)-catalyzed reaction of diazo compounds with terminal alkynes: A direct synthesis of trisubstituted furans

A method for the synthesis of tri-substituted furans has been developed based on Cu(I)-catalyzed reaction of terminal alkynes with β-keto α-diazoesters. This method for the synthesis of 2,3,5-trisubstituted furans is operationally simple and applicable to

Silver-mediated oxidative C-H/C-H functionalization: A strategy to construct polysubstituted furans

A novel silver-mediated highly selective oxidative C-H/C-H functionalization of 1,3-dicarbonyl compounds with terminal alkynes for the creation of polysubstituted furans and pyrroles in one step has been demonstrated. Promoted by the crucial silver specie

One-pot synthesis of furans using base- and acid-supported reagents Na 2CO3/Al2O3-PPA/SiO2'

A convenient method for the one-pot synthesis of furans from -keto esters and -halo ketones was developed using an acid- and base-supported reagent system Na2CO3/Al2O3-PPA/SiO2'. The condensation reaction of triketones, which are formed from the reaction of -keto esters with -halo ketones in the presence of Na2CO 3/Al2O3, was promoted by PPA/SiO2 to give the corresponding furans in good yields. This method is simple and easy to perform in comparison with stepwise processes, and the yields are good.

HETEROCYCLIC COMPOUND

The present invention provides a heterocyclic compound represented by the following formula (I), which has a glucagon antagonistic action and is useful for the prophylaxis or treatment of diabetes and the like, a compound represented by wherein ring A is an optionally substituted benzene ring and the like; Y is a nitrogen atom and the like; X is -O- and the like; R4 is a hydrogen atom and the like; R5 and R6 are each independently a hydrogen atom and the like; R1 is an optionally substituted hydrocarbon group and the like; R2 is a hydrogen atom and the like; and R3 is -(CH2)3-COOH and the like, or a salt thereof.