111853-41-9Relevant academic research and scientific papers
Synthesis of novel pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines, pyrido [3″,2″:4′,5′]thieno[3′,2′:4,5] pyrimido[1,6-a]benzimidazoles and related fused systems
Bakhite,Al-Sehemi,Yamada
, p. 1069 - 1077 (2007/10/03)
3-Amino-4-aryl-5-ethoxycarbonyl-6-methylthieno[2,3-b]pyridine-2- carboxamides 3a-c were prepared from ethyl 4-aryl-3-cyano-6-methyl-2-thioxo-1,2- dihydropyridine-5-carbonylates 1a-c and reacted with some carbonyl compounds to give tetrahydropyridothienopyrimidine derivatives 6a-c, 7a-c and 8a-c, respectively. Treatment of compound 3c with chloroacetyl chloride led to the formation of a next key compound, ethyl 2-chloromethyl-4-oxo-3,4- dihydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-8-carboxylate 9. Also, 3-amino-2-benzimidazolylthieno[2,3-b]pyridine-5-carboxylate 5 and 2-(3′-aminothieno [2,3-b]pyridin-2′-yl)-4-oxo-3,4- dihydropyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-8-carboxylate 17 were prepared from 1c. The compounds 5, 9 and 17 were used as good synthons for other pyridothienopyrimidines and pyridothienopyrimidobenzimidazoles as well as for related fused polyheterocyclic systems.
SYNTHESIS OF 3-AMINO-6-METHYL-5-ETHOXYCARBONYL-4,7-DIHYDROTHIENOPYRIDINE DERIVATIVES
Krauze, A. A.,Liepin'sh, E. E.,Pelcher, Yu. E.,Dubur,G. Ya.
, p. 102 - 106 (2007/10/02)
The alkylation of piperidinium salts of substituted 1,4-dihydropyridine-2-thiols with chloroacetonitrile or iodoacetamide gave 2-cyanomethylthio- and 2-carbamoylmethylthio-substituted 6-methyl-4-aryl(pyridyl)-5-ethoxycarbonyl-3-cyano-1,4-dihydropyridines, which undergo intramolecular cyclization in basic media to give 3-amino-6-methyl-4-aryl(pyridyl)-5-ethoxycarbonyl-2-cyano(carbamoyl)-4,7-dihydrothienopyridines.
