111879-79-9

Upstream product

• 174390-08-0 1-hydroperoxy-16-oxabicyclo[10.4.0]hexadecane 
• 251988-05-3 15-tetrahydro-2H-2-pyranyloxy-4-pentadecyn-1-ol 
• 251987-12-9 15-hydroxy-(Z)-11-pentadecenoic acid 
• 3003-84-7 Tetrahydrofurfuryl chloride 
• 251988-08-6 15-hydroxy-(Z)-4-pentadecenyl acetate 
• 51795-88-1 1-bromo-10-(tetrahydropyranyloxy)decane 

Downstream Products

• 4617-33-8 15-hydroxylpentadecanoic acid 
• 401942-46-9 15-hydroxy-11 ⁽¹²⁾-pentadecenoic acid 

Relevant academic research and scientific papers

PROCESS FOR PREPARING UNSATURATED LACTONES

The invention relates to a process for preparing saturated or unsaturated lactones. This process involves reacting a bicyclic compound or a monocyclic compound with hydrogen peroxide in the presence of a first acid having a pKa of 3 or less and a first organic solvent, thereby forming a hydroperoxide. The obtained mixture comprising the hydroperoxide is subsequently metered to a mixture of a second organic solvent and a dissociation-enhancing catalyst, optionally comprising a second organic acid. The invention also pertains to a process of preparing the hydroperoxide.

An improved and novel approach to macrolactonisation using di-tert-butyl dicarbonate

A new, facile, mild and simple method for the synthesis of macrolides was achieved from ω- hydroxy acids using di-tertbutyl dicarbonate (Boc2O), a cheap and commercially available reagent. A wide range of substrates were tested and give good yield of lactones. The effect of various simple bases on the yield of the macrolactonisation reaction was also studied.