111969-65-4

Upstream product

• 71338-71-1 benzyl (E)-2-butenoate 
• 85252-42-2 C₁₉H₂₇NO₃ 
• 71338-71-1 benzyl crotonate 
• 112020-51-6 C₁₉H₂₇NO₃ 
• 26315-61-7 L-menthyl glyoxylate 
• 622-30-0 N-benzyl hydroxylalmine 
• 111969-64-3 L-menthyl glyoxylate monohydrate 

Downstream Products

• 111969-66-5 (3S,4S)-3-<(R)-1'-hydroxyethyl>-4-(-)-menthyloxycarbonylazetidin-2-one 
• 111969-67-6 (3S,4S)-4-(-)-menthyloxycarbonyl-1-dimethyl-t-butylsilyl-3-<(R)-1-(dimethyl-t-butylsilyloxy)ethyl>azetidin-2-one 

Relevant academic research and scientific papers

CHIRAL SYNTHESIS OF 3--4-OXOAZETIDIN-2-YL ACETATE USING AN ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION REACTION

3--4-oxoazetidin-2-yl acetate (4; R = H), a key intermediate for the preparation of penem and carbapenem antibiotics was synthesized in an optically active form using a 1,3-dipolar cycloaddition reaction of a chiral nitrone (6) as a key step.

ASYMMETRIC SYNTHESIS OF 4-ACETOXY-3HYDROXYETHYLAZETIDIN-2-ONE, A KEY INTERMEDIATE FOR THE PREPARATION OF PENEM AND CARBAPENEM ANTIBIOTICS

Asymmetric synthesis of 4-acetoxy-3-hydroxyethylazetidin-2-one with desired stereochemistry has been achieved by employing dipolar cycloaddition of a chiral nitrone with benzyl crotonate as a key reaction.