85252-42-2

Upstream product

• 111969-64-3 L-menthyl glyoxylate monohydrate 
• 622-30-0 N-benzyl hydroxylalmine 
• 26315-61-7 L-menthyl glyoxylate 

Downstream Products

• 115936-61-3 (3R,4S,5R)-2-benzyl-4-benzyloxycarbonyl-3-(-)-menthyloxycarbonyl-5-methylisoxazolidine 
• 111969-65-4 (3S,4S,5R)-2-benzyl-4-benzyloxycarbonyl-3-(-)-menthyloxycarbonyl-5-methylisoxazolidine 
• 111969-65-4 (3S,4R,5S)-2-benzyl-4-benzyloxycarbonyl-3-(-)-menthyloxycarbonyl-5-methylisoxazolidine 
• 115831-80-6 (3S,4R)-3-<(R)-1'-hydroxyethyl>-4-(-)menthyloxycarbonyl-1-dimethyl-t-butylsilylazetidin-2-one 
• 111969-66-5 (3S,4S)-3-<(R)-1'-hydroxyethyl>-4-(-)-menthyloxycarbonylazetidin-2-one 
• 111969-66-5 (3S,4R)-3-<(R)-1'-hydroxyethyl>-4-(-)-menthyloxycarbonylazetidin-2-one 
• 111969-67-6 (3S,4S)-4-(-)-menthyloxycarbonyl-1-dimethyl-t-butylsilyl-3-<(R)-1-(dimethyl-t-butylsilyloxy)ethyl>azetidin-2-one 
• 111969-67-6 (3S,4R)-3-<(R)-1'-(dimethyl-t-butylsilyloxy)ethyl>-4-(-)-menthyloxycarbonyl-1-dimethyl-t-butylsilylazetidin-2-one 
• 85280-25-7 trans-2-benzyl-3-carbomenthoxy-5-phenylisoxazolidine 
• 85225-33-8 cis-2-benzyl-3-carbomenthoxy-5-phenylisoxazolidine 
• 85225-36-1 cis-2-benzyl-3-hydroxymethyl-5-phenylisoxazolidine 
• 85225-36-1 trans-2-benzyl-3-hydroxymethyl-5-phenylisoxazolidine 
• 1050549-73-9 (benzyl-hydroxy-amino)-(1H-pyrrol-2-yl)acetic acid (1R,2S,5R)-2-isopropyl-5-menthylcyclohexyl ester 

Relevant academic research and scientific papers

CHIRAL SYNTHESIS OF 3--4-OXOAZETIDIN-2-YL ACETATE USING AN ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION REACTION

3--4-oxoazetidin-2-yl acetate (4; R = H), a key intermediate for the preparation of penem and carbapenem antibiotics was synthesized in an optically active form using a 1,3-dipolar cycloaddition reaction of a chiral nitrone (6) as a key step.

ASYMMETRIC SYNTHESIS OF 4-ACETOXY-3HYDROXYETHYLAZETIDIN-2-ONE, A KEY INTERMEDIATE FOR THE PREPARATION OF PENEM AND CARBAPENEM ANTIBIOTICS

Asymmetric synthesis of 4-acetoxy-3-hydroxyethylazetidin-2-one with desired stereochemistry has been achieved by employing dipolar cycloaddition of a chiral nitrone with benzyl crotonate as a key reaction.

CYCLOADDITION OF CHIRAL NITRONES. THE -(-)-CARBOMENTHOXY MOIETY AS AN INDUCING GROUP

The feasibility of asymmetric synthesis for 2,3,5-trisubstituted isoxazolidines obtained in the 1,3-cycloaddition reaction of corresponding nitrones with olefines was investigated.The chiral factor was the -(-)-carbomenthoxy group, introduced wi