111978-56-4Relevant articles and documents
Ruthenium nanoparticle catalyzed selective reductive amination of imine with aldehyde to access tertiary amines
Li, Bin,Liu, Shun,Lin, Qiao,Shao, Yan,Peng, Shiyong,Li, Yibiao
, p. 9214 - 9217 (2018)
Reductive amination is one of the most frequently used transformations in organic synthesis. Herein, we developed a novel ruthenium nanoparticle embedded ordered mesoporous carbon catalyst (Ru-OMC) and a new hydrosilylation process for the synthesis of tertiary amines. We present a direct reductive amination of imines (CN bond) with aldehydes (CO bond) using hydrosilane as the reducing reagent under mild conditions. Moreover, the Ru-OMC catalysts can be reused for up to 14 runs without noticeably losing activity.
“One pot” synthesis of tertiary amines: Ru(II) catalyzed direct reductive N-benzylation of imines with benzyl bromide derivatives
Li, Bin,Yu, Jinghao,Li, Caihua,Li, Yibiao,Luo, Jianli,Shao, Yan
, p. 137 - 141 (2017)
The direct reductive N-benzylation of imines by reaction with benzyl bromide derivatives, in the presence of [RuCl2(p-cymene)]2catalyst and PhSiH3, is performed under mild conditions without additional base. This reaction proceeds by a tandem imine hydrosilylation/nucleophilic substitution with benzyl bromide derivatives to result the tertiary amines.
Synthesis of benzidine derivatives via FeCl3·6H 2O-promoted oxidative coupling of anilines
Ling, Xuege,Xiong, Yan,Huang, Ruofeng,Zhang, Xiaohui,Zhang, Shuting,Chen, Changguo
, p. 5218 - 5226 (2013/07/25)
Under open-flask conditions in the presence of commercially available FeCl3·6H2O, N,N-disubstituted anilines can be converted into diversely functionalized benzidines with yields of up to 99%. Oxidative coupling was extended to N-monosubstituted anilines, and the method was applied to the efficient preparation of 6,6′-biquinoline. Mechanistic investigations have also been performed to explain the observed reactivities.
