112004-83-8

Basic information

• Product Name: 4,4'-BIS(TRIMETHYLACETOXY)BENZOPHENONE
• Synonyms: SALOR-INT L172154-1EA;4,4'-BIS(TRIMETHYLACETOXY)BENZOPHENONE;4-(4-((2,2-DIMETHYLPROPANOYL)OXY)BENZOYL)PHENYL PIVALATE;2,2-DiMethyl-propanoic Acid 4-[4-(2,2-DiMethyl-1-oxopropoxy)benzoyl]phenyl Ester;4,4a€-Bis(trimethylacetoxy)benzophenone;Carbonylbis(4,1-phenylene) bis(2,2-dimethylpropanoate);4,4'-Dipivaloyloxybenzophenone
• CAS NO: 112004-83-8
• Molecular Formula: C₂₃H₂₆O₅
• Molecular Weight: 382.45
• Product Categories: Aromatics
• Mol File: 112004-83-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 173-174°C
• Boiling Point: 495.2°C at 760 mmHg
• Flash Point: 213.3°C
• Appearance: /
• Density: 1.118g/cm³
• Vapor Pressure: 6.05E-10mmHg at 25°C
• Refractive Index: 1.534
• Solubility: Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: 4,4'-BIS(TRIMETHYLACETOXY)BENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-BIS(TRIMETHYLACETOXY)BENZOPHENONE(112004-83-8)
• EPA Substance Registry System: 4,4'-BIS(TRIMETHYLACETOXY)BENZOPHENONE(112004-83-8)

Safety Data

• Hazardous Substances Data: 112004-83-8(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Solid

InChI:InChI=1/C23H26O5/c1-22(2,3)20(25)27-17-11-7-15(8-12-17)19(24)16-9-13-18(14-10-16)28-21(26)23(4,5)6/h7-14H,1-6H3

Upstream product

• 611-99-4 4,4'-Dihydroxybenzophenone 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 938077-66-8 [2-(4-hydroxyphenyl)-1-hexene-1,1-diyl]dibenzene-4,1-diyl bis(2,2-dimethylpropanoate) 
• 835889-78-6 phosphoric acid 2-(4-{4-[2-(1-acetyl-5-methyl-7-nitro-2,3-dihydro-1H-indol-4-yloxy)-ethoxy]-benzoyl}-phenoxy)-ethyl ester di-tert-butyl ester 
• 835889-77-5 4-{2-[di(tert-butoxy)phosphoryloxy]ethoxy}-4'-(trimethylacetoxy)benzophenone 
• 835889-71-9 4-{2-[di(tert-butoxy)phosphoryloxy]ethoxy}-4'-hydroxybenzophenone 
• 835889-76-4 4-(2-hydroxyethoxy)-4'-(trimethylacetoxy)benzophenone 
• 114031-67-3 [4-(4-hydroxybenzoyl)phenyl]-2,2-dimethyl propanoate 
• 112005-07-9 4,4'-bis(pivaloyloxy)benzhydrol 

Relevant articles and documents

New highly stereoselective synthesis of (Z)-4-hydroxytamoxifen and (Z)-4-hydroxytoremifene via McMurry reaction

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NOVEL ARYL ETHANE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

The present invention relates to an aryl ethene derivative, for inhibiting an estrogen-related receptor gamma (ERRγ) activity, a prodrug of same, a solvate of same, a stereoisomer of same or pharmaceutically acceptable salts of same, and a pharmaceutical

Synthesis and biological evaluation of novel 4-hydroxytamoxifen analogs as estrogen-related receptor gamma inverse agonists

Estrogen-related receptor gamma (ERRγ) has recently been recognized as an attractive target for treating inflammation, cancer, and metabolic disorders. Herein, we discovered and demonstrated the in vitro pharmacology as well as the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of chemical entities that could act as highly selective inverse agonists for ERRγ. The results were comparable to those for GSK5182 (4), a leading ERRγ inverse agonist ligand. Briefly, the half-maximal inhibitory concentration (IC50) range of the synthesized compounds for ERRγ was 0.1-10 μM. Impressively, compound 24e exhibited potency comparable to 4 but was more selective for ERRγ over three other subtypes: ERRα, ERRβ, and estrogen receptor α. Furthermore, compound 24e exhibited a superior in vitro ADMET profile compared to the other compounds. Thus, the newly synthesized class of ERRγ inverse agonists could be lead candidates for developing clinical therapies for ERRγ-related disorders.