112078-72-5

Basic information

• Product Name: 2H-1-Benzopyran-2-one, 4-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-
• CAS NO: 112078-72-5
• Molecular Formula: C16H12O6
• Molecular Weight: 300.268
• Mol File: 112078-72-5.mol

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-2-one, 4-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-2-one, 4-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-(112078-72-5)
• EPA Substance Registry System: 2H-1-Benzopyran-2-one, 4-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-(112078-72-5)

Safety Data

• Hazardous Substances Data: 112078-72-5(Hazardous Substances Data)

Upstream product

• 2174-64-3 5-methoxyresorcinol 
• 909007-90-5 3,4-dibenzyloxyabenzoylacetic ethyl ester 
• 28924-21-2 3,5-dibenzyloxyacetophenone 
• 51863-60-6 3,5-dihydroxyacetophenone 
• 116310-58-8 5-O-β-D-glucopyranosyl-7-methoxy-3′,4′-dihydroxy-4-phenylcoumarin 

Relevant articles and documents

REVISED STRUCTURE OF NEOFLAVONE IN COUTAREA HEXANDRA

A new neoflavone isolated from Coutarea hexandra, thought to be 5,2', 5'-trihydroxy-7-methoxyneoflavone, is now shown to be 5,3',4'-trihydroxy-methoxyneoflavone by synthesis.Key Word Index - Coutarea hexandra; Legominosae; 5,2',5'-trihydroxy-7-methoxyneoflavone; 5,3',4'-trihydroxy-7-methoxyneoflavone.

Effects of the neoflavonoid coutareagenin, one of the antidiabetic active substances of Hintonia latiflora, on streptozotocin-induced diabetes mellitus in rats

In the present study, diabetes mellitus was induced with streptozotocin in Wistar rats from the inbred strain F > 28, and a blood sugar lowering effect due to the oral or intragastric administration of a copalchi native extract (Hintoniae latiflorae cortex) or intragastric administration of the pure substance, coutareagenin (neoflavonoid) (5-hydroxy-7-methoxy-4-(3,4- dihydroxyphenyl)-2H-benzo-1-pyran-2-on), was demonstrated with statistically significant results. This study enlarged and confirmed the results of earlier studies by other authors with regard to the antidiabetic effect of the copalchi bark extract in various animal species with hyperglycemia induced by different methods. By the use of the synthetically produced neoflavonoid, coutareagenin, the present series of tests provided evidence that coutareagenin, one of the active substances contained in Hintonia latiflora bark (Copalchi bark), produces a reduction of diabetic elevated blood sugar levels. The native extract as a whole, however, has to be regarded as the active substance (active substance complex) of Hintonia latiflora (Copalchi) bark.

4-ARYLCOUMARIN GLYCOSIDES FROM COUTAREA HEXANDRA

The caulis of Coutarea hexandra was found to contain four new 4-arylcoumarin glycosides: 5-O-(β-D-glucopyranosyl)-7,3',4'-trihydroxy-4-phenylcoumarin; 5-O-(β-D-glucopyranosyl)-7-methoxy-3',4'-dihydroxy-4-phenylcoumarin; 5-O-6)-β-D-glucopyranosyl>-7,3',4'-trihydroxy-4-phenylcoumarin and 5-O-6)-β-D-glucopyranosyl>-7-methoxy-3',4'-dihydroxy-4-phenylcoumarin.The structures were assigned by chemical and spectroscopic methods.Key Word Index-Countarea hexandra; Rubiaceae; 4-arycoumarin glycosides; 1H and 13C NMR, FABMS.