909007-90-5Relevant articles and documents
A novel diketo phosphonic acid that exhibits specific, strand-transfer inhibition of HIV integrase and anti-HIV activity
Chi, Guochen,Nair, Vasu,Semenova, Elena,Pommier, Yves
, p. 1266 - 1269 (2007)
We have synthesized novel phosphonic acid analogues of β-diketo acids. Interestingly, the phosphonic acid isostere, 2, of our anti-HIV compound, 1, was an inhibitor of only the strand transfer step, in stark contrast to 1. Compound 2 had lower anti-HIV ac