1590360-52-3Relevant academic research and scientific papers
Copper-catalyzed intramolecular cyclization of N-propargyl-adenine: Synthesis of purine-fused tricyclics
Li, Ren-Long,Liang, Lei,Xie, Ming-Sheng,Qu, Gui-Rong,Niu, Hong-Ying,Guo, Hai-Ming
, p. 3665 - 3670 (2014/05/06)
A novel protocol to construct fluorescent purine-fused tricyclic products via intramolecular cyclization of N-propargyl-adenine has been developed. With CuBr as the catalyst, a series of purine-fused tricyclic products were obtained in good to excellent yields (19 examples, 75-89% yields). When R2 was a hydrogen atom in N-propargyl-adenines, the reactions only afforded the endocyclic double bond products. When R2 was an aryl group, the electron-donating groups favored the endocyclic double bond products, while the electron-withdrawing groups favored the exocyclic double bond products.
