1121-44-4

Basic information

• Product Name: 2-Propylpyrrolidine
• Synonyms: 2-propylpyrrolidine(SALTDATA: HCl)
• CAS NO: 1121-44-4
• Molecular Formula: C₇H₁₅N
• Molecular Weight: 113.2007
• Product Categories: pharmacetical
• Mol File: 1121-44-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 149.8 °C at 760 mmHg
• Flash Point: 34.5 °C
• Appearance: /
• Density: 0.815 g/cm³
• Vapor Pressure: 3.96mmHg at 25°C
• Refractive Index: 1.428
• CAS DataBase Reference: 2-Propylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propylpyrrolidine(1121-44-4)
• EPA Substance Registry System: 2-Propylpyrrolidine(1121-44-4)

Safety Data

• Hazardous Substances Data: 1121-44-4(Hazardous Substances Data)

Usage

General Description

2-Propylpyrrolidine is a chemical compound with the molecular formula C8H17N. It is a saturated, cyclic secondary amine that is commonly used as a building block in organic synthesis. 2-Propylpyrrolidine is a colorless to pale yellow liquid with a pungent, amine-like odor. It is used in the production of pharmaceuticals and agrochemicals, as well as in the synthesis of other fine chemicals. It is also used as a solvent in various chemical processes. 2-Propylpyrrolidine is classified as a skin and eye irritant and can be harmful if swallowed or inhaled, so proper safety measures must be taken when handling this chemical.

InChI:InChI=1/C7H15N/c1-2-4-7-5-3-6-8-7/h7-8H,2-6H2,1H3

Upstream product

• 111-68-2 1-Heptylamine 
• 38427-89-3 (N-tert-Butyloxycarbonyl)heptylamine 
• 676132-43-7 α-allyl-N-benzyloxycarbonylpyrrolidine 
• 20293-45-2 2-allylpyrrole 
• 103085-20-7 N-methylsulfonylheptylamine 
• 616-45-5 2-pyrrolidinon 
• 56-23-5 tetrachloromethane 
• 927-77-5 n-propylmagnesium bromide 
• 4428-38-0 3-(furan-2-yl)propan-1-amine 
• 7732-18-5 water 
• 103085-21-8 1-(methylsulfonyl)-2-propylpyrrolidine 
• 1551-08-2 2-n-propylpyrrole 

Downstream Products

• 6508-94-7 2-propyl-1-tosylpyrrolidine 
• 81333-30-4 N-[4-(2-Propyl-pyrrolidine-1-sulfonyl)-phenyl]-acetamide; hydrochloride 
• 81333-27-9 2-Propyl-N-(phenylcarbamoyl)pyrrolidine 
• 13332-35-9 1-benzenesulfonyl-2-propyl-pyrrolidine 

Relevant articles and documents

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Triiodide-Mediated δ-Amination of Secondary C?H Bonds

The Cδ?H amination of unactivated, secondary C?H bonds to form a broad range of functionalized pyrrolidines has been developed by a triiodide (I3?)-mediated strategy. By in situ 1) oxidation of sodium iodide and 2) sequestration of the transiently generated iodine (I2) as I3?, this approach precludes undesired I2-mediated decomposition which can otherwise limit synthetic utility to only weak C(sp3)?H bonds. The mechanism of this triiodide-mediated cyclization of unbiased, secondary C(sp3)?H bonds, by either thermal or photolytic initiation, is supported by NMR and UV/Vis data, as well as intercepted intermediates.

High regioselectivity in electrochemical α-methoxylation of N-protected cyclic amines

N-Protecting groups of α-substituted cyclic amines strongly affected the regioselectivity in electrochemical methoxylation of these compounds. Namely, N-acyl derivatives were transformed into α′-methoxylated compounds, while N-cyano derivatives changed into α-methoxylated derivatives. Furthermore, Lewis acid catalyzed nucleophilic substitution of the α-methoxylated compounds protected with cyano group afforded α,α-disubstituted cyclic amines.