1121-44-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Production:
2-Propylpyrrolidine is utilized as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with potential therapeutic and pesticidal properties, contributing to advancements in healthcare and agriculture.
Used in Fine Chemical Synthesis:
2-Propylpyrrolidine is also employed in the production of other fine chemicals, where its reactivity and structural features are leveraged to create specialty products for various applications, including fragrances, dyes, and other industrial chemicals.
Used as a Solvent in Chemical Processes:
2-Propylpyrrolidine's solubility properties make it a suitable solvent for a range of chemical processes. It facilitates reactions by dissolving reactants and providing a medium for chemical transformations, thus enhancing the efficiency and yield of these processes.
Used in Research and Development:
Due to its reactivity and structural characteristics, 2-Propylpyrrolidine is often used in research and development settings to explore new chemical reactions, synthesize novel compounds, and study the properties of various chemical systems.

InChI:InChI=1/C7H15N/c1-2-4-7-5-3-6-8-7/h7-8H,2-6H2,1H3

Upstream product

• 103085-21-8 1-(methylsulfonyl)-2-propylpyrrolidine 
• 4428-38-0 3-(furan-2-yl)propan-1-amine 
• 7732-18-5 water 
• 616-45-5 2-pyrrolidinon 
• 56-23-5 tetrachloromethane 
• 927-77-5 n-propylmagnesium bromide 
• 20293-45-2 2-allylpyrrole 
• 38427-89-3 (N-tert-Butyloxycarbonyl)heptylamine 
• 676132-43-7 α-allyl-N-benzyloxycarbonylpyrrolidine 
• 103085-20-7 N-methylsulfonylheptylamine 
• 111-68-2 1-Heptylamine 
• 1551-08-2 2-n-propylpyrrole 

Downstream Products

• 13332-35-9 1-benzenesulfonyl-2-propyl-pyrrolidine 
• 81333-27-9 2-Propyl-N-(phenylcarbamoyl)pyrrolidine 
• 81333-30-4 N-[4-(2-Propyl-pyrrolidine-1-sulfonyl)-phenyl]-acetamide; hydrochloride 
• 6508-94-7 2-propyl-1-tosylpyrrolidine 

Relevant academic research and scientific papers

O-benzoylhydroxylamines as alkyl nitrene precursors: Synthesis of saturated N-heterocycles from primary amines

We introduce O-benzoylhydroxylamines as competent alkyl nitrene precursors. The combination of readily available, stable substrates and a proficient rhodium catalyst provides a straightforward means for the construction of various pyrrolidine rings from the corresponding primary amines. Preliminary mechanistic investigation suggests that the structure of the nitrene precursor plays a role in determining the nature of the resulting reactive intermediate.

Triiodide-Mediated δ-Amination of Secondary C?H Bonds

The Cδ?H amination of unactivated, secondary C?H bonds to form a broad range of functionalized pyrrolidines has been developed by a triiodide (I3?)-mediated strategy. By in situ 1) oxidation of sodium iodide and 2) sequestration of the transiently generated iodine (I2) as I3?, this approach precludes undesired I2-mediated decomposition which can otherwise limit synthetic utility to only weak C(sp3)?H bonds. The mechanism of this triiodide-mediated cyclization of unbiased, secondary C(sp3)?H bonds, by either thermal or photolytic initiation, is supported by NMR and UV/Vis data, as well as intercepted intermediates.

A novel synthesis of 2-alkyl(aryl)pyrrolidines from proline via 2,3-diphenylhexahydropyrrolo[2,1-b]oxazoles

Diphenyloxapyrrolizidines, products of the reaction between proline and benzaldehyde, are convenient building blocks for synthesizing 2-substituted pyrrolidines. The opening of their oxazolidine ring by treatment with Grignard reagents has been performed

High regioselectivity in electrochemical α-methoxylation of N-protected cyclic amines

N-Protecting groups of α-substituted cyclic amines strongly affected the regioselectivity in electrochemical methoxylation of these compounds. Namely, N-acyl derivatives were transformed into α′-methoxylated compounds, while N-cyano derivatives changed into α-methoxylated derivatives. Furthermore, Lewis acid catalyzed nucleophilic substitution of the α-methoxylated compounds protected with cyano group afforded α,α-disubstituted cyclic amines.

REGIOSPECIFIC OXIDATIVE CYCLIZATION OF N-METHYLSULFONYLAMINES INTO PYRROLIDINES

In the framework of the approach to remote oxidative functionalization of organic compounds of various classes, which is currently under exploration by us and which is based on reactions of element-centred free radicals, the regiospecific oxidative cyclization of N-methylsulfonylalkylamines 3 into N-methylsulfonylpyrrolidines 4 has been accomplished.The more facile isomerisation of intermediate sulfonamidyl radicals 8 with 1,5-H shift in comparison with their carboxamidyl analogues 16 is, in our opinion, the chemical proof of different electronic configurations of radicals 8 (? structure) and 16 (predominantly ? structure) generated under identical conditions using Na2S2O8-CuCl2 system.