1121-96-6

Basic information

• Product Name: 1,2-dithiolane-4,4-diyldimethanol
• Synonyms: 1,2-dithiolane-4,4-dimethanol; 1,2-Dithiolane-4,4-diyldimethanol
• CAS NO: 1121-96-6
• Molecular Formula: C₅H₁₀O₂S₂
• Molecular Weight: 166.2617
• Mol File: 1121-96-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 317.8°C at 760 mmHg
• Flash Point: 154.8°C
• Density: 1.349g/cm³
• Vapor Pressure: 3.12E-05mmHg at 25°C
• Refractive Index: 1.606
• CAS DataBase Reference: 1,2-dithiolane-4,4-diyldimethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dithiolane-4,4-diyldimethanol(1121-96-6)
• EPA Substance Registry System: 1,2-dithiolane-4,4-diyldimethanol(1121-96-6)

Safety Data

• Hazardous Substances Data: 1121-96-6(Hazardous Substances Data)

Usage

General Description

1,2-dithiolane-4,4-diyldimethanol is a chemical compound with the molecular formula C6H12S2O2. It is a colorless liquid with a strong, unpleasant odor, and it is soluble in water and most organic solvents. 1,2-dithiolane-4,4-diyldimethanol is used as a crosslinking agent in the production of polymers, as well as a chemical intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the production of adhesives, coatings, and sealants. 1,2-dithiolane-4,4-diyldimethanol is considered to be a hazardous chemical, and proper safety precautions should be taken when handling and storing it.

Upstream product

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Downstream Products

• 19333-66-5 2,2-bis(sulfanylmethyl)propane-1,3-diol 
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Relevant articles and documents

Self-crosslinkable and intracellularly decrosslinkable biodegradable micellar nanoparticles: A robust, simple and multifunctional nanoplatform for high-efficiency targeted cancer chemotherapy

Nanomedicines based on biodegradable micelles offer a most promising treatment for malignant tumors. Their clinical effectiveness, however, remains to be improved. Here, we report that self-crosslinkable and intracellularly decrosslinkable micellar nanoparticles (SCID-Ms) self-assembled from novel amphiphilic biodegradable poly(ethylene glycol)-b-poly(dithiolane trimethylene carbonate) block copolymer achieve high-efficiency targeted cancer chemotherapy in vivo. Interestingly, doxorubicin (DOX)-loaded SCID-Ms showed favorable features of superb stability, minimal drug leakage, long circulation time, triggered drug release inside the tumor cells, and an unprecedented maximum-tolerated dose (MTD) of over 100?mg DOX equiv./kg in mice, which was at least 10 times higher than free drug. The in vivo studies in malignant B16 melanoma-bearing C57BL/6 mice revealed that DOX-SCID-Ms at a dosage of 30?mg DOX equiv./kg could effectively suppress tumor growth and prolong mice survival time without causing obvious systemic toxicity. Moreover, DOX-SCID-Ms could be readily decorated with a targeting ligand like cRGD peptide. The biodistribution studies showed that cRGD20/DOX-SCID-Ms had a high tumor accumulation of 6.13% ID/g at 6?h post injection, which was ca. 3-fold higher than that for clinically used pegylated liposomal doxorubicin (DOX-LPs). Accordingly, cRGD20/DOX-SCID-Ms exhibited significantly better therapeutic efficacy and lower side effects than DOX-LPs in B16 melanoma-bearing mice. These self-regulating biodegradable micellar nanoparticles offer a robust, multifunctional and viable nanoplatform for targeted cancer chemotherapy.

Disulfide-containing five-membered ring cyclic carbonate functional groups of monomer and its preparation method

Disclosed are a cyclic carbonate monomer containing a double-sulfur five-membered ring functional group, and preparation method thereof. The cyclic carbonate monomer can be simply and efficiently synthesized without protection and deprotection processes. The cyclic carbonate monomer of the present invention can be utilized to obtain polycarbonate having a controllable molecular weight and molecular weight distribution via ring opening polymerization, and has biodegradability and reduction-sensitive reversible crosslinking properties. The present invention can be used in a carrier having controllably released drug, a biological tissue scaffold or a biochip.

ANTIOXIDANT POLYMERS CONTAINING [1,2]-DITHIOLANE MOIETIES AND USES THEREOF

The present invention describes polymers containing 1,2-dithiolanes capable of acting as scavengers of free radicals, metals and reactive oxygen species. Also described are methods of synthesizing the antioxidant 1,2-dithiolane derivatives and polymerization thereof to produce biodegradable antioxidant polymers. The antioxidant polymers of the present invention may be used to treat diseases or conditions caused by oxidative stress and other free radical mediated conditions. The antioxidant polymers may also be used for the preparation of antioxidant particulate delivery devices of therapeutic agents.