19333-66-5

Usage

Uses

Used in Pharmaceutical Applications:
2,2-bis(sulfanylmethyl)propane-1,3-diol is used as a therapeutic agent for the treatment of cystinuria, a genetic disorder. It functions as a chelating agent, binding to cystine molecules to form soluble complexes that can be safely excreted in urine, thus preventing the formation of harmful cystine stones in the kidneys, ureter, and bladder.
Used in Heavy Metal Detoxification:
2,2-bis(sulfanylmethyl)propane-1,3-diol is used as a detoxifying agent for heavy metals in the body. Its chelating properties allow it to bind to heavy metals, aiding in their removal and reducing potential toxicity.
Used in Combination Therapy:
2,2-bis(sulfanylmethyl)propane-1,3-diol is often used in conjunction with a high fluid intake regimen to enhance its effectiveness in preventing stone formation in patients with cystinuria. This approach helps to dilute and flush out the soluble cystine-cysteine complexes, further reducing the likelihood of stone development.

Upstream product

• 1121-96-6 4,4-Bis-hydroxymethyl-[1,2]dithiolan 
• 3296-90-0 bis(bromomethyl)bis(hydroxymethyl)methane 
• 132424-79-4 2,2-bis(acetylthiomethyl)-1,3-propandiol 
• 7647-01-0 hydrogenchloride 
• 109018-86-2 5,5-bis(acetylthiomethyl)-2,2-dimethyl-1,3-dioxan 
• 96587-74-5 2,2-dimethyl-5,5-bis-(toluene-4-sulfonyloxymethyl)-[1,3]dioxane 
• 1293392-03-6 5,5-dimethenyl-2,2-dimethyl-1,3-dioxane bis(thiocyanate) 
• 1293392-04-7 1,3-(hydroxymethyl)propane-1,3-diyl bis(thiocyanate) 
• 770-74-1 2,2-dimethyl-5,5-bis(hydroxymethyl)-1,3-dioxane 

Downstream Products

• 1121-96-6 4,4-Bis-hydroxymethyl-[1,2]dithiolan 
• 852899-06-0 5,5-bis-hydroxymethyl-2-methyl-2-phenyl-[1,3]dithiane 
• 1360541-83-8 3,9-bis(m-nitrophenyl)-2,4-dioxa-8,10-dithia-spiro[5.5]undecane 
• 1360541-85-0 3,9-bis(m-nitrophenyl)-2,8-dioxa-4,10-dithia-spiro[5.5]undecane 
• 1360541-84-9 3,9-bis(p-nitrophenyl)-2,4-dioxa-8,10-dithia-spiro[5.5]undecane 

Relevant academic research and scientific papers

OVARIAN CANCER SPECIFICALLY TARGETED BIODEGRADABLE AMPHIPHILIC POLYMER, POLYMER VESICLE PREPARED THEREBY AND USE THEREOF

Provided are an ovarian cancer specifically targeted biodegradable amphiphilic polymer, a polymer vesicle prepared thereby and use thereof. The biodegradable amphiphilic polymer is prepared by a polymer containing dithiocarbonate monomer bonded with targeting molecules. The polymer vesicle prepared with the biodegradable amphiphilic polymer can crosslink spontaneously without adding an extra crosslinker, and the crosslink has a reduction activity and hence can be used in drug controlled-release systems, and contributes to the clinical use and production of nano-drugs.

Disulfide-containing five-membered ring cyclic carbonate functional groups of monomer and its preparation method

Disclosed are a cyclic carbonate monomer containing a double-sulfur five-membered ring functional group, and preparation method thereof. The cyclic carbonate monomer can be simply and efficiently synthesized without protection and deprotection processes. The cyclic carbonate monomer of the present invention can be utilized to obtain polycarbonate having a controllable molecular weight and molecular weight distribution via ring opening polymerization, and has biodegradability and reduction-sensitive reversible crosslinking properties. The present invention can be used in a carrier having controllably released drug, a biological tissue scaffold or a biochip.

Molecular rods based on oligo-spiro-thioketals

We report on an extension of the previously established concept of oligospiroketal (OSK) rods by replacing a part or all ketal moieties by thioketals leading to oligospirothioketal (OSTK) rods. In this way, some crucial problems arising from the reversible formation of ketals are circumvented. Furthermore, the stability of the rods toward hydrolysis is considerably improved. To successfully implement this concept, we first developed a number of new oligothiol building blocks and improved the synthetic accessibility of known oligothiols, respectively. Another advantage of thioacetals is that terephthalaldehyde (TAA) sleeves, which are too flexible in the case of acetals can be used in OSTK rods. The viability of the OSTK approach was demonstrated by the successful preparation of some OSTK rods with a length of some nanometers.

Synthesis and stereochemistry of new spiro[5.5]undecane derivatives with 1,3-dioxane, 1,3-dithiane, or 1,3-oxathiane rings

The synthesis and the structural investigations of spiro[5.5]undecane derivatives with S and O containing heterocycles, exhibiting similar [bis(1,3-oxathiane) spiranes] or different (1,3-dioxane-1,3-dithiane spiranes) heterocycles, in the spirane units are reported. Springer Science+Business Media, LLC 2011.

The mixed diol-dithiol 2,2-bis-(sulfanylmethyl)propane-1,3-diol: Characterization of key intermediates on a new synthetic pathway

A new synthetic route to 2,2-bis(sulfanylmethyl)propane-1,3-diol, (II), is described starting from the commercially available 2,2-bis(hydroxymethyl) propane-1,3-diol. The structures of two intermediates on this route are described. 5,5-Dimethenyl-2,2-dimethyl-1,3-dioxane bis(thiocyanate) (systematic name: {[5-(cyanosulfanyl)-2,2-dimethyl-1,3-dioxan-5-yl]sulfan-yl}formo-nitrile), C10H14N2O2S2, (X), crystallizes in the space group P21/c with no symmetry relationship between the two thio-cyanate groups. There is a short intra-molecular N...S contact for one thio-cyanate group, while the second group is positioned such that this type of interaction is not possible. 1,3-(Hydroxymethyl)propane-1,3- diyl bis(thiocyanate), C7H10N2O 2S2, (XI), also features a single short N...S contact in the solid state. Hydrogen bonding between two mol-ecules of compound (XI) results in the formation of dimers in the crystal, which are then linked together by a second hydrogen-bond interaction between the dimers. In addition, the structures of two inter-mediates from an unsuccessful alternative synthesis of (II) are reported. 2,2-Bis(chloromethyl)propane-1,3-diol, C5H 10Cl2O2, (VI), crystallized as an inversion twin with a minor twin fraction of 0.43 (6). It forms a zigzag structure as a result of intermolecular hydrogen bonding. The structure of 9,9-di-methyl-2,4,8, 10-tetraoxa-3λ4-thiaspiro-[5.5]undecan-3-one, C 8H14O5S, (VII), shows evidence for a weak S...O contact with a distance of 3.2529 (11) A.