112110-07-3

Usage

Uses

Used in Pharmaceutical Industry:
5-Trifluoromethyl-pyridin-3-ylamine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with improved efficacy and selectivity. Its unique structure allows for the creation of molecules with specific biological activities, making it a valuable component in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Trifluoromethyl-pyridin-3-ylamine is utilized as a precursor in the production of pesticides and other crop protection agents. Its incorporation into these compounds can enhance their effectiveness in controlling pests and diseases, thereby contributing to increased agricultural productivity.
Used in Research Laboratories:
5-Trifluoromethyl-pyridin-3-ylamine is employed as a reagent in research settings for the synthesis of complex organic molecules. Its presence in these reactions can facilitate the formation of desired products, making it an indispensable tool for chemists working on the development of novel organic compounds.
Overall, 5-Trifluoromethyl-pyridin-3-ylamine is a versatile chemical with significant applications in various industries, particularly in the development and synthesis of pharmaceuticals, agrochemicals, and complex organic molecules in research. Its unique properties and reactivity make it an essential component in the advancement of these fields.

InChI:InChI=1/C6H5F3N2/c7-6(8,9)4-1-5(10)3-11-2-4/h1-3H,10H2

Upstream product

• 85148-26-1 3-chloro-5-(trifluoromethyl)pyridine 
• 72587-15-6 2-chloro-3-nitro-5-(trifluoromethyl)pyridine 
• 99368-67-9 2-chloro-5-nitro-3-(trifluoromethyl)pyridine 
• 436799-33-6 3-bromo-5-(trifluoromethyl)pyridine 
• 1529769-93-4 1,1-diphenyl-N-[5-(trifluoromethyl)-3-pyridyl]methanimine 

Downstream Products

• 1036376-09-6 4-methyl-3-(9H-pyrimido[4,5-b]indol-7-yl)-N-[5-(trifluoromethyl)pyridin-3-yl]benzamide 
• 919278-36-7 phenyl [5-(trifluoro-methyl)pyridin-3-yl]carbamate 
• 1187055-62-4 cis-3-(Boc-amino)-5-(trifluoromethyl)piperidine 
• 1405128-48-4 cis-(+/-)-tert-butyl 5-(trifluoromethyl)piperidin-3-ylcarbamate 
• 130291-25-7 2,6-bis(4'-benzylpiperidin-1'-ylmethyl)-4-(7''-trifluoromethyl-1'',5''-naphthyridin-4''-ylamino)phenol 
• 130291-22-4 2,6-bis(3',5'-dimethylpiperidin-1'-ylmethyl)-4-(7''-trifluoromethyl-1'',5''-naphthyridin-4''-ylamino)phenol 
• 130291-21-3 2,6-bis(3'-methylpiperidin-1'-ylmethyl)-4-(7''-trifluoromethyl-1'',5''-naphthyridin-4''-ylamino)phenol 
• 130291-23-5 2,6-bis(4'-methylpiperidin-1'-ylmethyl)-4-(7''-trifluoromethyl-1'',5''-naphthyridin-4''-ylamino)phenol 

Relevant academic research and scientific papers

Synthesis method of aminopyridine compounds

The invention provides a synthesis method of aminopyridine compounds. The synthesis method of the aminopyridine compounds comprises the following steps: under a heating condition, halogenated pyridineorganic matters and an ammoniation reagent are subjected to an ammoniation reaction to obtain an ammoniated product system, wherein in the ammoniation reaction, the temperature of the ammoniation reaction is 200-240 DEG C, and the ammoniation reagent is in a solid state and can be decomposed to generate ammonia gas; and the ammoniated product system is sequentially purified and salified to obtainthe aminopyridine compounds. The synthesis method does not need to add a solvent, so that the yield of three wastes can be greatly reduced; the type of the ammonification reagent and the ammonification reaction temperature are limited during the reaction process, such that the high reaction rate and the high conversion rate can be obtained without the addition of the catalyst, and the purification and salification process after the ammonification reaction is simple and has the good separation effect so as to substantially reduce the production cost and improve the product yield and the product purity. In addition, the synthesis method also has the advantages of good repeatability and the like.

Oxalic amide ligands, and uses thereof in copper-catalyzed coupling reaction of aryl halides

The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C—N, C—O and C—S bonds.

Assembly of Primary (Hetero)Arylamines via CuI/Oxalic Diamide-Catalyzed Coupling of Aryl Chlorides and Ammonia

A general and practical catalytic system for aryl amination of aryl chlorides with aqueous or gaseous ammonia has been developed, with CuI as the catalyst and bisaryl oxalic diamides as the ligands. The reaction proceeds at 105-120°C to provide a diverse set of primary (hetero)aryl amines in high yields with various functional groups.

CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS

Provided are cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer are also provided.

CYCLOPROPANECARBOXAMIDO-SUBSTITUTE AROMATIC COMPOUNDS AS ANTI-TUMOR AGENTS

Provided are cyclopropanecarboxamido-substituted aromatic compounds that inhibit protein kinases and their use in anti-tumor area. In particular, tyrosine-kinase inhibitors and Raf-kinase inhibitors as anti-tumor agents, their preparation, pharmaceutical composition, and their use in the treatment of cancer are also provided.

Mild and highly selective palladium-catalyzed monoarylation of ammonia enabled by the use of bulky biarylphosphine ligands and palladacycle precatalysts

A method for the Pd-catalyzed arylation of ammonia with a wide range of aryl and heteroaryl halides, including challenging five-membered heterocyclic substrates, is described. Excellent selectivity for monoarylation of ammonia to primary arylamines was achieved under mild conditions or at rt by the use of bulky biarylphosphine ligands (L6, L7, and L4) as well as their corresponding aminobiphenyl palladacycle precatalysts (3a, 3b, and 3c). As this process requires neither the use of a glovebox nor high pressures of ammonia, it should be widely applicable.

Pyridyloxyindoles Inhibitors of VEGF-R2 and Use Thereof for Treatment of Disease

The invention relates to novel organic compounds of formula (I), and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in the treatment of tumour diseases and ocular neovascular diseases.

N-Phenyl-N′-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases

We have recently reported the discovery of pyrrolo[3,2-d]pyrimidine derivatives 1a and 1b as potent triple inhibitors of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and Tie-2 kinases. To identify compounds having strong inhibitory activity against fibroblast growth factor receptor (FGFR) kinase, further modification was conducted using the co-crystal structure analysis of VEGFR2 and 1b. Among the compounds synthesized, urea derivative 11l having a piperazine moiety on the terminal benzene ring showed strong inhibitory activity against FGFR1 kinase as well as VEGFR2 kinase. A binding model of 11l complexed with VEGFR2 suggested that the piperazine moiety forms additional interactions with Ile1025 and His1026.

SUBSTITUTED HETEROCYCLES AS JANUS KINASE INHIBITORS

The present invention provides substituted tricyclic heteroaryl compounds, including, for example, pyridoindoles, pyrimidinoindoles and triazinoindoles that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases such as immune-related diseases, skin disorders, myeloid proliferative disorders, cancer, and other diseases.

3-AMINOCYCLOPENTANECARBOXAMIDES AS MODULATORS OF CHEMOKINE RECEPTORS

The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment of diseases related to chemokine receptor expression and/or activity.