130291-19-9Relevant articles and documents
Potential Antimalarials. X Di-Mannich Bases of 4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino)phenol and N-(4'-Diethylamino-1'-methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4-amine
Barlin, Gordon B.,Jiravinyu, Chuenjit
, p. 1175 - 1181 (2007/10/02)
The syntheses of some di-Mannich bases derived from 4-(7'-trifluoromethyl-1',5'-naphthyridin-4'-ylamino) phenol and of N-(4'-diethylamino-1'-methylbutyl)-7-trifluoromethyl-1,5-naphthyridin-4-amine from 3-chloro-5-trifluoromethylpyridine via 4-chloro-7-trifluoromethyl-1,5-naphthyridine are described.In tests in vitro against the FCQ-27 strain of Plasmodium falciparum these compounds were slightly less active than their 7-bromo analogues.