112116-24-2

Upstream product

• 4672-50-8 1,6-bis(p-toluenesulfonyloxy)hexane 
• 100-83-4 meta-hydroxybenzaldehyde 
• 2163-00-0 1,6-dichlorohexane 
• 98-59-9 p-toluenesulfonyl chloride 
• 629-03-8 1 ,6-dibromohexane 

Downstream Products

• 862803-25-6 (CH₂)6(OC₆H₄CH(OH)CCH)2 
• 1401456-79-8 N,N'-(5,5'-(3,3'-(hexane-1,6-diylbis(oxy))bis(3,1-phenylene))bis(4-acetyl-4,5-dihydro-1,3,4-thiadiazole-5,2-diyl))diacetamide 
• 1401456-66-3 2,2'-(3,3'-(hexane-1,6-diylbis(oxy))bis(3,1-phenylene))bis(methan-1-yl-1-ylidene)bis(hydrazinecarbothioamide) 
• 798577-28-3 (CH₂)6(OC₆H₄C(O)CCH)2 

Relevant academic research and scientific papers

Synthesis, Antimicrobial Evaluations, and DNA Photo Cleavage Studies of New Bispyranopyrazoles

The bispyranopyrazoles (4a, 4b, 4c, 4d, 4e, 4f, 4g) were synthesized from the reactions of dibenzaldehydes (2a, 2b, 2c, 2d, 2e, 2f, 2g) with 3-methylpyrazole-5-one 3 and malononitrile by refluxing under alcoholic medium. The dibenzaldehydes were obtained from the O-alkylation of 3-hydroxybenzaldehyde with suitable 1,ω-dibromoalkanes under the alkaline conditions in the presence of dry EtOH/DMF. The structures of bisheterocyclics were determined from rigorous analysis of their spectral parameters (IR,1H-NMR,13C-NMR, and ESI-MS). The newly prepared compounds were screened for their antimicrobial activity against seven bacterial and five fungal strains. The DNA photo cleavage potential of these compounds was also evaluated by using agarose gel electrophoresis, and bispyranopyrazoles 4b, 4d and 4e exhibited significant level of DNA photocleavage activity.

Overcoming Strain-Induced Rearrangement Reactions: A Mild Dehydrative Aromatization Protocol for Synthesis of Highly Distorted p-Phenylenes

A series of p-terphenyl-based macrocycles, containing highly distorted p-phenylene units, have been synthesized. Biaryl bonds of the nonplanar p-terphenyl nuclei were constructed in the absence of Pd-catalyzed or Ni-mediated cross-coupling reactions, usin

One-pot synthesis of bis(4,5-diphenylimidazol-2-yl-phenyl)glycols and evaluation of their antimicrobial activity

Abstract A new series of bis(4,5-diphenylimidazol-2-yl-phenyl)glycols were synthesized by reaction of bis(formylphenyl)glycols with benzil/benzoin and ammonium acetate in presence of iodine/acetic acid in ethanol. All newly synthesized compounds were char

Novel Bis(2-(5-((5-phenyl-1H-tetrazol-1-yl)methyl)-4H-1,2,4-triazol-3-yl)phenoxy)Alkanes: Synthesis and Characterization

In this study, 10 different substituted aromatic bis-benzaldehydes were synthesized by treating hydroxy benzaldehydes with various dihaloalkanes. Bis aldehydes 5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j were treated with 2-(5-phenyl-1H-tetrazole-1-yl)acetohyd

New 1,3,4-bisthiadiazolines: Synthesis, characterization and antimicrobial evaluations

The bisthiadiazolines 4a-4g have been synthesized in good yields from the cyclization reactions of bisthiosemicarbazones 3a-3g with acetic anhydride. The condensation reaction of dibenzaldehydes 2a-2g with thiosemicarbazide in alcoholic medium provided 3a

Bis(oxyphenylene)benzimidazoles: A novel class of anti-Plasmodium falciparum agents

A small library of 26 2,2′-[alkane-α,ω- diylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and evaluated against Giardia intestinalis, Entamoeba histolytica, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium

A new route to hyperbranched macromolecules: Syntheses of photosensitive poly(aroylarylene)s via 1,3,5-regioselective polycyclotrimerization of bis(aroylacetylene)s

A new synthetic route to hyperbranched polymers is developed. Polycyclotrimerizations of functional diynes 1-3 initiated by a simple base of piperidine lead to the formation of hyperbranched poly(aroylarylene)s P1-P3 with perfect 1,3,5-regioregularity and

Synthesis and photocyclization of macrocyclic stilbene derivatives

The stereoselectivity of the formation of macrocyclic stilbenes as well as the regioselectivity of their photocyclization are strongly influenced by the length of the connecting alkanediyl chain. The stereoisomers of the macrocyclic stilbenes and the corr

Investigation of the one-flask synthesis of porphyrins bearing meso-linked straps of variable length, rigidity, and redox activity

The reactions of 18 dialdehydes have been examined in the two-step one-flask room temperature porphyrin synthesis. Efficient alkylation methods were established for the reaction of diols and diacids with bromomethylbenzaldehyde. Dialdehydes linked at the o,o'- or m,m'-positions were converted to strapped porphyrins in yields up to 25%, while the one p,p'-linked dialdehyde that was examined failed to give porphyrin. The resulting porphyrins bear straps joining adjacent, meso-positions rather than across the face of the porphyrin. Dialdehydes incorporating rigid groups provided improved yields in some but not all cases. The yield of strapped porphyrin exhibited a maximum at 10-2 M reactant concentrations. The o,o'-strapped porphyrins exist as atropisomers that are sufficiently stable to interconversion at room temperature to be separable chromatographically. No atropisomers of m,m'-strapped porphyrins could be separated, though some could be observed by 1H NMR spectroscopy. For two different m,m'-strapped porphyrins, the ΔG values for interconversion of the atropisomers were found to be 66 and 68 kJ/mol. The outer rings in these strapped porphyrins range in size from 14 to 24 atoms. Five porphyrins with bridging redox-active groups (ferrocene or anthraquinone) have been prepared in one-flask reactions, including a porphyrin bearing one ferrocene and one anthraquinone in straps across adjacent meta-substituted phenyl sites.