112157-39-8

Usage

Uses

Used in Biochemical Research:
N2-[(Phenylmethoxy)carbonyl]-L-lysine tert-Butyl Ester is used as a reactant for the preparation of deoxypyridinoline, a biochemical marker of collagen turnover. This application is crucial for studying and monitoring the rate of collagen synthesis and degradation in various physiological and pathological conditions.
Used in Pharmaceutical Development:
In the pharmaceutical industry, N2-[(Phenylmethoxy)carbonyl]-L-lysine tert-Butyl Ester serves as a key reactant in the preparation of a series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA). These inhibitors hold potential in the development of targeted therapies for prostate cancer treatment, showcasing the compound's importance in advancing cancer research and drug discovery.

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 2212-75-1 N₂-[(benzyloxy)carbonyl]-L-lysine 
• 105751-18-6 N_α-carbobenzyloxy-N_ε-9-fluorenylmethoxycarbonyl-L-lysine 

Downstream Products

• 171287-52-8 C₂₁H₃₂N₂O₅ 
• 127623-77-2 tert-butyl (S)-2-benzyloxycarbonylamino-6-hydroxyhex-5-enoate 
• 495401-20-2 tert-butyl (S)-2-(((benzyloxy)carbonyl)amino)-6-hydroxyhexanoate 
• 869111-55-7 (3S,5S,6R)-3-[(R)-4-((S)-5-Benzyloxycarbonylamino-5-tert-butoxycarbonyl-pentylamino)-3-hydroxy-butyl]-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid tert-butyl ester 
• 869111-59-1 (3S,5S,6R)-3-[(S)-4-((S)-5-Benzyloxycarbonylamino-5-tert-butoxycarbonyl-pentylamino)-3-hydroxy-butyl]-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid tert-butyl ester 
• 171287-62-0 [(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-yl]-carbamic acid benzyl ester 
• 171287-63-1 (R)-N-[(S)-1-(tert-Butyl-diphenyl-silanyloxy)-2-oxo-azepan-3-yl]-3-hydroxy-butyramide 
• 171287-55-1 (S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid tert-butyl ester 
• 210547-90-3 (S)-3-Amino-1-(tert-butyl-diphenyl-silanyloxy)-azepan-2-one 
• 495401-25-7 4-[(S)-2-benzyloxycarbonylamino-2-(tert-butyloxycarbonyl)ethyl]-5-[(S)-3-benzyloxycarbonylamino-3-(tert-butyloxycarbonyl)propyl]-1-[(2R,5S)-5-benzyloxycarbonylamino-5-(allyloxycarbonyl)-2-hydroxypentyl]-3-pyridiniumolate 
• 495401-26-8 4-[(S)-2-benzyloxycarbonylamino-2-(tert-butyloxycarbonyl)ethyl]-5-[(S)-3-benzyloxycarbonylamino-3-(tert-butyloxycarbonyl)propyl]-1-[(2R,5S)-5-benzyloxycarbonylamino-5-carboxy-2-hydroxypentyl]-3-pyridiniumolate 
• 441353-28-2 allyl (2S,5R)-2-benzyloxycarbonylamino-5-hydroxy-6-iodohexanoate 
• 495401-21-3 tert-butyl (2S)-2-benzyloxycarbonylamino-6-bromo-5-hydroxyhexanoate 
• 254106-02-0 tert-butyl N-[(benzyloxy)carbonyl]-6-iodo-L-norleucinate 

Relevant academic research and scientific papers

Synthesis of enantiomers of N-(2-aminopurin-6-yl)amino acids

Nonracemic N-(2-aminopurin-6-yl)-substituted amino acids were synthesized by nucleophilic substitution of chlorine atom in 2-acetamido-6-chloropurine upon treatment with amino acid tert-butyl esters and subsequent removal of protecting groups. Their enant

Preparation of isodesmosine-KLH conjugate for ELISA system

Chronic obstructive pulmonary disease (COPD) is a degenerative condition with limited diagnostic detection efficiency. Currently with no available cure, COPD is associated with irreversible elastic tissue degradation in lungs, which results in release of

NOVEL GLUTAMINE ANALOGS

The invention relates to novel glutamine analogs shown as the formula I, a composition containing the glutamine analogs and the use thereof.

Method for the synthesis of deoxypyridinoline

Disclosed is a method for the chemical synthesis of deoxypyridinoline (DPD). The synthesis involves the preparation of a protected 3-hydroxypyridinium starting with a Nα-protected lysine and a 5,6-epoxy-2-N-protected-O-protected-(2S)-2-aminohexanoate with

Total synthesis of a mycobactin S, a siderophore and growth promoter of Mycobacterium Smegmatis, and determination of its growth inhibitory activity against Mycobacterium tuberculosis

A general total synthesis of mycobactins, represented by a mycobactin S, was achieved by a convergent approach. Two hydroxamic acid residues, 28 and 40b, were prepared from commercially available N(α)-Cbz-L-lysine via dimethyldioxirane oxidations. Cycliza

Heme binding compounds and use thereof

Inhibitors of nitric oxide formation from arginine useful for treating hypotension, inflammation, stroke and to restore vascular contractile sensitivity to the effects of α1 adrenergic agonists are physiologically active compounds including Ns

An Efficient Synthesis of Cobactin T, a Key Component of the Mycobactin Class of Siderophores

Nα-Cbz-L-lysine t-butyl ester was oxidized by dimethyldioxirane to give nitrone 8c, which was converted to azopine derivative 15.Subsequent coupling and deprotection reactions afforded an efficient synthesis of cobactin T (19).

S-alkyl-isothioureido-amino acids and use thereof

Inhibitors of nitric oxide formation from arginine useful for treating hypotension, inflammation, stroke and to restore vascular contractile sensitivity to the effects of α1 -adrenergic agonists are physiologically active compounds including Nδ -substituted ornithine or Nε -substituted lysine moieties or monoalkyl carbon-substituted Nδ -substituted ornithine or Nε -substituted lysine moieties, having the formula STR1 wherein R is (CH2)y CH3 or H, R' is CH2 or C(H)(CH2)y CH3, and R" is CH2 or C(H)(CH2)y CH3, with y ranging from 0 to 5, and x is 0 or 1 and wherein none or only one of R, R' and R" provides an alkyl substituent on ornithine or lysine moiety, and wherein Q is alkyl having 1 to 5 carbon atoms, and physiologically acceptable acid addition salts thereof.