1121583-62-7

Basic information

• Product Name: isopropyl 2-propoxyacetate
• CAS NO: 1121583-62-7
• Molecular Weight: 160.213
• Mol File: 1121583-62-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: isopropyl 2-propoxyacetate(CAS DataBase Reference)
• NIST Chemistry Reference: isopropyl 2-propoxyacetate(1121583-62-7)
• EPA Substance Registry System: isopropyl 2-propoxyacetate(1121583-62-7)

Safety Data

• Hazardous Substances Data: 1121583-62-7(Hazardous Substances Data)

Upstream product

• 54497-00-6 2-n-propoxyacetic acid 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 19144-86-6 (S)-N-acetyl-1-phenylethylamine 
• 4187-54-6 (S)-N-[1-(4-nitrophenyl)ethyl]acetamide 
• 186296-21-9 (S)-N-[1-(4-chlorophenyl)ethyl]acetamide 
• 186296-23-1 (S)-N-(1-(4-bromophenyl)ethyl)acetamide 
• 20306-86-9 (S)-N-(1-phenylpropyl)acetamide 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 4187-57-9 (S)-1-methyl-3-phenylpropylamine 
• 123-82-0 (S)-2-heptylamine 
• 4187-53-5 (S)-1-(p-nitrophenyl)ethylamine 
• 4187-56-8 (S)-1-(p-chlorophenyl)ethylamine 
• 27298-97-1 (S)-1-(4-bromophenyl)ethylamine 
• 3789-59-1 (R)-1-phenylpropylamine 
• 65451-89-0 (S)-1-(3',4'-dimethoxyphenyl)ethylamine 

Relevant articles and documents

Optimization of 2-alkoxyacetates as acylating agent for enzymatic kinetic resolution of chiral amines

In this study, the activity of acetic acid esters modified with electron withdrawing 2-alkoxy-groups was investigated as acylating agent in kinetic resolution (KR) of racemic amines. A homologous series of the isopropyl esters of four 2-alkoxyacetic acids (2-methoxy-, 2-ethoxy-, 2-propoxy- and 2-butoxyacetic acids) were prepared and investigated for enantiomer selective N-acylation, catalyzed by lipase B from Candida antarctica, under batch and continuous-flow conditions. In the first set of experiments, isopropyl 2-propoxyacetate showed the highest effectivity with all of the four racemic amines [(±)-1-phenylethylamine, (±)-4-phenylbutan-2-amine, (±)-heptan-2-amine and (±)-1-methoxypropane-2-amine] in the set enabling excellent conversions (≥46%) and enantiomeric excess values (ee ≥ 99%) with each amines in continuous-flow mode KRs under the optimized reaction conditions. In a second set of experiments, KRs of five additional amines – being substituted derivatives of (±)-1-phenylethylamine – further demonstrated the usefulness of isopropyl 2-propoxyacetate – being the best acylating agent in the first set of KRs – in KRs leading to (R)-N-propoxyacetamides with high ee values (≥99.8%).