54497-00-6

Basic information

• Product Name: PROPOXYACETICACID
• Synonyms: PROPOXYACETICACID;propoxyacetic acid(SALTDATA: FREE);Acetic acid, 2-propoxy-
• CAS NO: 54497-00-6
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.13
• Mol File: 54497-00-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 112-115℃ (15 Torr)
• Flash Point: 94.7±13.3℃
• Appearance: /
• Density: 1.054±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.0337mmHg at 25°C
• Refractive Index: 1.40511 (20℃)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.55±0.10(Predicted)
• CAS DataBase Reference: PROPOXYACETICACID(CAS DataBase Reference)
• NIST Chemistry Reference: PROPOXYACETICACID(54497-00-6)
• EPA Substance Registry System: PROPOXYACETICACID(54497-00-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 54497-00-6(Hazardous Substances Data)

Usage

General Description

Propoxyacetic acid, also known as 1-methoxypropanoic acid, is a chemical compound with the molecular formula C5H10O3. It is a colorless liquid with a faint odor and is commonly used as an intermediate in organic synthesis and in the production of pharmaceuticals and agrochemicals. Propoxyacetic acid is also used as a reagent in the manufacturing of perfumes and fragrances. It is considered a relatively stable and non-hazardous compound, with low volatility and low potential for bioaccumulation. Additionally, it has low toxicity and is not expected to cause adverse effects on human health or the environment when used as intended. However, as with all chemicals, proper handling and disposal practices should be followed to minimize potential risks.

InChI:InChI=1/C5H10O3/c1-2-3-8-4-5(6)7/h2-4H2,1H3,(H,6,7)

Upstream product

• 6819-41-6 sodium n-propoxide 
• 79-11-8 chloroacetic acid 
• 71-23-8 propan-1-ol 
• 3926-62-3 sodium monochloroacetic acid 
• 66502-25-8 propoxyacetonitrile 

Downstream Products

• 1121583-62-7 isopropyl 2-propoxyacetate 
• 68836-61-3 N-(n-propoxymethylformyl)-4-chloro-α,α,α-trifluorotoluidine 
• 32048-66-1 N-[4-(3-cyclohexyl-2-imino-imidazolidine-1-sulfonyl)-phenethyl]-2-propoxy-acetamide 
• 915381-34-9 N-(2-amino-5-bromopyridin-3-yl)-2-propoxyacetamide 

Relevant articles and documents

Preparation method of 2-n-propoxy acetyl chloride

The invention relates to the field of chemical synthesis of 2-n-propoxy acetyl chloride, and discloses a preparation method of 2-n-propoxy acetyl chloride. The preparation method comprises the following steps: (1) reacting sodium chloroacetate with alkali in an n-propyl alcohol solvent to obtain a mixture containing a component shown by formula (I); (2) distilling the mixture to obtain a product from which part of n-propyl alcohol is removed; (3) adding water into the obtained product and distilling the product to replace residual n-propyl alcohol in the product, so as to obtain a product containing water and the component shown by formula (I); (4a) adding acid to the product obtained in step (3), extracting the product with a water-insoluble solvent, and reacting the product with an acylating agent to obtain 2-n-propoxy acetyl chloride shown in formula (III); or, (4B) reacting the product obtained in step (3) with an acylating reagent to obtain 2-n-propoxy acetyl chloride shown in formula (III), wherein formula (I), formula (II) and formula (III) are as described in the specification. The method provided by the invention has mild reaction conditions, less solvent consumption, highproduct yield and less byproducts.

PYRIDINE [2,3-B] PYRAZINONES

Compounds of Formula (I), wherein R2, Y6, R6A, R6, and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.