112192-04-8 Usage
Uses
Used in Pharmaceutical Industry:
Roxindole Hydrochloride is used as a therapeutic agent for the treatment of Parkinson's disease. As a D-2 dopamine autoreceptor agonist, it helps to increase dopamine levels in the brain, which can alleviate the motor symptoms associated with Parkinson's disease, such as tremors, rigidity, and bradykinesia.
Additionally, due to its ability to modulate dopamine levels, Roxindole Hydrochloride may also have potential applications in the treatment of other neurological disorders characterized by dopamine imbalances, such as schizophrenia and addiction. However, further research is needed to fully understand its potential applications and efficacy in these areas.
Biological Activity
Dopamine D 2 autoreceptor agonist, with affinity for D 3 , D 4 and 5-HT 1 receptors (pK i values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D 2 , D 3 , D 4 , 5-HT 1A , 5-HT 1B and 5-HT 1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 112192-04-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,1,9 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 112192-04:
(8*1)+(7*1)+(6*2)+(5*1)+(4*9)+(3*2)+(2*0)+(1*4)=78
78 % 10 = 8
So 112192-04-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H26N2O/c26-21-9-10-23-22(16-21)20(17-24-23)8-4-5-13-25-14-11-19(12-15-25)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,24,26H,4-5,8,12-15H2
112192-04-8Relevant academic research and scientific papers
A straightforward synthetic approach for roxindole
Lange, Jos H. M.,De Jong, Johannes C.,Sanders, Hans J.,Visser, Geb M.,Kruse, Chris G.
, p. 1055 - 1056 (2007/10/03)
A concise synthetic approach to the dopamine autoreceptor agonist roxindole 1 has been devised. The key step in the novel route is the addition of succinic anhydride to 5-methoxyindolylmagnesium bromide, which circumvents the cumbersome construction of th
Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1- pyridylalkyl)indoles. A novel conformational model to explain structure- activity relationships
Bottcher,Barnickel,Hausberg,Haase,Seyfried,Eiermann
, p. 4020 - 4026 (2007/10/02)
The synthesis and dopaminergic properties of a novel type of dopamine agonist is described. The number and kind of essential structural elements differ significantly from that of the rigid apomorphine-type dopamine agonists. Using standard molecular modeling techniques, a conformational model is developed proposing a U-shaped conformation which might be energetically preferred through aromatic π-π-interactions between both of the electron rich aromatic structural elements of this class of compounds. Superimposition of conformations of the lead compound 28 with apomorphine yields a novel model explaining the atypical structure-activity relationships found in this class of indolealkylamines.
