112196-59-5

Upstream product

• 112196-58-4 (S)-methyl-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-((tert-butyldimethyl-silyl)oxy)phenyl)propanoate 
• 112196-57-3 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-((tert-butyldimethylsilyl)-oxy)phenyl)propanoate 
• 60-18-4 L-tyrosine 
• 4326-36-7 (S)-N-(tert-butoxycarbonyl)tyrosine methyl ester 
• 1080-06-4 L-Tyr-OMe 
• 24424-99-5 di-tert-butyl dicarbonate 
• 70963-39-2 N-methyl-L-tyrosine methyl ester 

Downstream Products

• 70963-39-2 N-methyl-L-tyrosine methyl ester 
• 82038-34-4 (S)-2-((tert-butoxycarbonyl)(methyl)amino)-3-(4-hydroxyphenyl)propanoic acid 
• 113982-07-3 methyl 3-bromo-5-chloro-N-methyl-L-tyrosinate 
• 113982-06-2 methyl N-Boc-3-bromo-5-chloro-N-methyl-L-tyrosinate 
• 114014-11-8 methyl N-Cbz-3,5-dichloro-N-methyl-L-tyrosyl-3-bromo-5-chloro-N-methyl-L-tyrosinate 
• 112196-64-2 2-{[(S)-2-({(S)-2-[(S)-2-{[(S)-2-((R)-2-Amino-propionylamino)-propionyl]-methyl-amino}-3-(4-methoxy-phenyl)-propionylamino]-propionyl}-methyl-amino)-3-(4-hydroxy-phenyl)-propionyl]-methyl-amino}-3-(4-hydroxy-phenyl)-propionic acid; compound with trifluoro-acetic acid 
• 112196-65-3 C₅₁H₅₉F₅N₆O₁₂ 
• 112196-61-9 Boc-D-Ala-Ala-N-Me-Tyr(OMe)-Ala-N-Me-Tyr-N-Me-Tyr-OMe 
• 112196-62-0 Boc-D-Ala-Ala-N-Me-Tyr(OMe)-Ala-N-Me-Tyr-N-Me-Tyr-OH 
• 91502-34-0 cyclo-N-methyl-L-tyr-N-methyl-L-tyr-D-ala-L-ala-O,N-dimethyl-L-tyr-L-ala 
• 84254-47-7 methyl N-boc-N-methyl-L-tyr-N-methyl-L-tyrosinate 
• 112196-60-8 H-N-Me-Tyr-N-Me-Tyr-OMe 
• 112196-67-5 C₄₆H₅₁F₅N₆O₁₀*C₂HF₃O₂ 
• 808196-27-2 isoquinoline-5-sulfonic acid 2,6-dibromo-4-[2-[(isoquinoline-5-sulfonyl)-methyl-amino]-3-oxo-3-(4-o-tolyl-piperazin-1-yl)-propyl]-phenyl ester 

Relevant academic research and scientific papers

TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS

Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).

Regioselective synthesis of 14-membered biaryl ethers: Total synthesis of RA-VII and deoxybouvardin

In order to obtain a key compound (22a'') for synthesis of RA-VII (1) and deoxybouvardin (2), construction of the 14-membered ring system was performed by means of thallium trinitrate-mediated oxidation of the tetrahalogeno amides 5-7. The dibromo dichlor