7584-11-4

Basic information

• Product Name: 2-Cyano-4,6-dimethylpyridine
• Synonyms: 2-Cyano-4,6-dimethylpyridine
• CAS NO: 7584-11-4
• Molecular Formula: C₈H₈N₂
• Molecular Weight: 132.16252
• Mol File: 7584-11-4.mol

Chemical Properties

• Melting Point: 53-53.5 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 272.179 °C at 760 mmHg
• Flash Point: 102.72 °C
• Appearance: /
• Density: 1.056 g/cm³
• Storage Temp.: 2-8°C
• PKA: 1.06±0.10(Predicted)
• CAS DataBase Reference: 2-Cyano-4,6-dimethylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyano-4,6-dimethylpyridine(7584-11-4)
• EPA Substance Registry System: 2-Cyano-4,6-dimethylpyridine(7584-11-4)

Safety Data

• Hazardous Substances Data: 7584-11-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Cyano-4,6-dimethylpyridine is used as an intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Cyano-4,6-dimethylpyridine is used as a key component in the preparation of cis-dihydroxylation and epoxidation of olefins with hydrogen peroxide. This application is crucial for the production of various chemicals and materials with specific properties and functions.
Used in Agrochemical Industry:
2-Cyano-4,6-dimethylpyridine is also utilized in the agrochemical industry for the development of new pesticides and other agrochemical products. Its incorporation into these products can enhance their effectiveness and selectivity, leading to improved crop protection and yield.
Used in Material Science:
In material science, 2-Cyano-4,6-dimethylpyridine can be employed in the development of novel materials with specific properties, such as improved stability, reactivity, or selectivity. These materials can find applications in various fields, including electronics, coatings, and adhesives.

Upstream product

• 30838-93-8 2-chloro-4,6-dimethyl-pyridine 
• 1122-45-8 2,4-dimethylpyridine N-oxide 
• 77-78-1 dimethyl sulfate 
• 1118-58-7 1,3-Dimethyl-1,3-butadien 
• 460-19-5 ethanedinitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 108-47-4 2,4-lutidine 

Downstream Products

• 71208-75-8 1-benzyl-2-pyrrolyl 4,6-dimethyl-2-pyridyl ketone 
• 76457-15-3 1-(4,6-dimethylpyridin-2-yl)methanamine 
• 79076-48-5 E-2-<5-(benzylmethylamino)-1-penten-1-yl>-4,6-dimethylpyridine 
• 79076-68-9 2-(1-benzyl-2-pyrrolidinylmethyl)-4,6-dimethylpyridine 
• 71381-49-2 2-(1-benzyl-2-pyrrolylmethyl)-1,4,6-trimethylpyridinium iodide 
• 71208-76-9 2-(1-benzyl-2-pyrrolylmethyl)-4,6-dimethylpyridine 
• 5439-01-0 4,6-dimethylpyridine-2-carbaldehyde 
• 18088-10-3 4,6-dimethylpyridine-2-carboxylic acid 
• 18087-99-5 4,6-dimethyl-2-(hydroxymethyl)pyridine 

Relevant articles and documents

COMPOUNDS AND THEIR USE AS PDE4 ACTIVATORS

The present invention relates to compounds as defined herein, which are activators of long form cyclic nucleotide phosphodiesterase-4 (PDE4) enzymes (isoforms) and to therapies using these activators. In particular, the invention relates to these activator compounds for use in a method for the treatment or prevention of disorders requiring a reduction of second messenger responses mediated by cyclic 3',5-adenosine monophosphate (cAMP).

Fe(PyTACN)-catalyzed cis-dihydroxylation of olefins with hydrogen peroxide

A family of iron complexes with general formula [Fe(II)( R,Y,XPyTACN)(CF3SO3)2], where R,Y,XPyTACN=1-[2′-(4-Y-6-X-pyridyl)methyl]-4,7-dialkyl-1,4, 7-triazacyclononane, X and Y refer to the groups at positions 4 and 6 of the pyridine, respectively, and R refers to the alkyl substitution at N-4 and N-7 of the triazacyclononane ring, are shown to be catalysts for efficient and selective alkene oxidation (epoxidation and cis-dihydroxylation) employing hydrogen peroxide as oxidant. Complex [Fe(II)(Me,Me,HPyTACN)(CF 3SO3)2] (7), was identified as the most efficient and selective cis-dihydroxylation catalyst among the family. The high activity of 7 allows the oxidation of alkenes to proceed rapidly (30 min) at room temperature and under conditions where the olefin is not used in large amounts but instead is the limiting reagent. In the presence of 3 mol% of 7, 2 equiv. of H2O2 as oxidant and 15 equiv. of water, in acetonitrile solution, alkenes are cis-dihydroxylated reaching yields that might be interesting for synthetic purposes. Competition experiments show that 7 exhibits preferential selectivity towards the oxidation of cis olefins over the trans analogues, and also affords better yields and high [syn-diol]/[epoxide] ratios when cis olefins are oxidized. For aliphatic substrates, reaction yields attained with the present system compare favourably with state of the art Fe-catalyzed cis-dihydroxylation systems, and it can be regarded as an attractive complement to the iron and manganese systems described recently and which show optimum activity against electron-deficient and aromatic olefins. Copyright