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112233-64-4

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112233-64-4 Usage

General Description

The chemical compound ".beta.-D-Glucopyranose, 1,6-anhydro-3-deoxy-3-fluoro-4-O-(phenylmethyl)-" is a synthetic derivative of glucose that has been modified by the addition of a fluoro and phenylmethyl group. It is a rare sugar molecule that has potential applications in pharmaceuticals and as a chemical building block for the synthesis of other compounds. The modification of the glucose molecule may impart specific biological activities or properties that are not present in natural glucose. The compound's structure and properties make it a subject of interest for research and development in the fields of medicinal chemistry and organic synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 112233-64-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,2,3 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 112233-64:
(8*1)+(7*1)+(6*2)+(5*2)+(4*3)+(3*3)+(2*6)+(1*4)=74
74 % 10 = 4
So 112233-64-4 is a valid CAS Registry Number.

112233-64-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,6-anhydro-4-O-benzyl-3-deoxy-3-fluoro-β-D-glucopyranose

1.2 Other means of identification

Product number -
Other names (1R,2R,3R,4S,5R)-2-Benzyloxy-3-fluoro-6,8-dioxa-bicyclo[3.2.1]octan-4-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:112233-64-4 SDS

112233-64-4Downstream Products

112233-64-4Relevant articles and documents

Stereoselective Synthesis of Fluorinated Galactopyranosides as Potential Molecular Probes for Galactophilic Proteins: Assessment of Monofluorogalactoside–LecA Interactions

Denavit, Vincent,Lainé, Danny,Bouzriba, Chahrazed,Shanina, Elena,Gillon, émilie,Fortin, Sébastien,Rademacher, Christoph,Imberty, Anne,Giguère, Denis

supporting information, p. 4478 - 4490 (2019/03/07)

The replacement of hydroxyl groups by fluorine atoms on hexopyranoside scaffolds may allow access to invaluable tools for studying various biochemical processes. As part of ongoing activities toward the preparation of fluorinated carbohydrates, a systematic investigation involving the synthesis and biological evaluation of a series of mono- and polyfluorinated galactopyranosides is described. Various monofluorogalactopyranosides, a trifluorinated, and a tetrafluorinated galactopyranoside have been prepared using a Chiron approach. Given the scarcity of these compounds in the literature, in addition to their synthesis, their biological profiles were evaluated. Firstly, the fluorinated compounds were investigated as antiproliferative agents using normal human and mouse cells in comparison with cancerous cells. Most of the fluorinated compounds showed no antiproliferative activity. Secondly, these carbohydrate probes were used as potential inhibitors of galactophilic lectins. The first transverse relaxation-optimized spectroscopy (TROSY) NMR experiments were performed on these interactions, examining chemical shift perturbations of the backbone resonances of LecA, a virulence factor from Pseudomonas aeruginosa. Moreover, taking advantage of the fluorine atom, the 19F NMR resonances of the monofluorogalactopyranosides were directly monitored in the presence and absence of LecA to assess ligand binding. Lastly, these results were corroborated with the binding potencies of the monofluorinated galactopyranoside derivatives by isothermal titration calorimetry experiments. Analogues with fluorine atoms at C-3 and C-4 showed weaker affinities with LecA as compared to those with the fluorine atom at C-2 or C-6. This research has focused on the chemical synthesis of “drug-like” low-molecular-weight inhibitors that circumvent drawbacks typically associated with natural oligosaccharides.

SYNTHESES OF 3-DEOXY-3-SUBSTITUTED-D-GLUCOSE DERIVATIVES. PART I. IMPROVEMENTS IN PREPARATION OF AND NUCLEOPHILIC ADDITIONS TO 1,6:2,3-DIANHYDRO-4-O-BENZYL-Β-D-ALLOPYRANOSE

Grindley, Bruce T.,Reimer, Gerry J.,Karlovec, Jaroslav,Brown, Robert G.,Andersob, Max

, p. 1065 - 1071 (2007/10/02)

The yield of the five-step preparation of 1,6:2,3-dianhydro-4-O-benzyl-β-D-glucopyranose from 1,6-anhydro-β-D-glucopyranose has been raised to 33percent from 12percent by modifying conditions or methods for four of the steps.It has been demonstrated that

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