1123194-96-6

Basic information

• Product Name: N-(6-bromo-2-methoxypyridin-3-yl)formamide
• Synonyms: N-(6-bromo-2-methoxypyridin-3-yl)formamide;N-(6-bromo-2-methoxy-3-pyridinyl)Formamide;N-(6-Bromo-2-Methoxy-3-Pyridinyl)Formamide(WXC03949);Formamide, N-(6-bromo-2-methoxy-3-pyridinyl)-
• CAS NO: 1123194-96-6
• Molecular Formula: C₇H₇BrN₂O₂
• Molecular Weight: 231.04668
• Mol File: 1123194-96-6.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(6-bromo-2-methoxypyridin-3-yl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(6-bromo-2-methoxypyridin-3-yl)formamide(1123194-96-6)
• EPA Substance Registry System: N-(6-bromo-2-methoxypyridin-3-yl)formamide(1123194-96-6)

Safety Data

• Hazardous Substances Data: 1123194-96-6(Hazardous Substances Data)

Upstream product

• 89466-18-2 6-bromo-2-methoxy-pyridin-3-ylamine 
• 462-08-8 pyridin-3-ylamine 
• 39856-57-0 2,6-dibromo-3-aminopyridine 
• 64-18-6 formic acid 
• 108-24-7 acetic anhydride 
• 2258-42-6 formyl acetic anhydride 

Downstream Products

• 1123194-98-8 6-bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridine 
• 1240608-99-4 [2-(4-fluorophenyl)-1-methyl-1H-benzoimidazol-4-yl]-[6-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine 
• 1240609-53-3 [2-(4-fluorophenyl)-1,6-dimethyl-1H-imidazo[4,5-c]pyridin-4-yl]-[6-methoxy-5-(4-methylimidazol-1-yl)pyridin-2-yl]amine 
• 1402004-16-3 7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydropyrido[2,1-c]-[1,4]oxazine-1,6-dione 
• 1262197-81-8 methyl 6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridine-2-carboxylate 

Relevant articles and documents

Synthesis of Pyridopyrazine-1,6-dione γ-Secretase Modulators via Selective 4-Methylimidazole N1-Buchwald Arylation

An efficient synthesis of pyridopyrazine-1,6-dione γ-secretase modulators (GSMs) is described. Our route features the construction of a crystalline lactone intermediate via a selective palladium-catalyzed 4-methylimidazole N1-arylation using the Buchwald Xantphos Pd G4 precatalyst, which does not require a preactivation step. The weak inorganic base KHCO3 was employed to minimize saponification of a particularly sensitive lactone substrate. Additional key transformations include DABAL-Me3-mediated lactone aminolysis and a mild TBD/ethyl trifluoroacetate mediated lactam ring closure to afford a representative GSM in high yield.

Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators

The evolution of gamma-secretase modulators (GSMs) through the introduction of novel heterocycles with the goal of aligning activity for reducing the levels of Aβ42 and properties consistent with a drug-like molecule are described. The insertion of a methoxypyridine motif within the tetracyclic scaffold provided compounds with improved activity for arresting Aβ42 production as well as improved properties, including solubility. In vivo pharmacokinetic analysis demonstrated that several compounds within the novel series were capable of crossing the BBB and accessing the therapeutic target. Treatment with methoxypyridine-derived compound 64 reduced Aβ42 levels in the plasma of J20 mice, in addition to reducing Aβ42 levels in the plasma and brain of Tg2576 mice.

OXADIAZINE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.