112372-06-2

Basic information

• Product Name: Furo[2,3-c]pyridine-2-carboxaldehyde (9CI)
• Synonyms: Furo[2,3-c]pyridine-2-carboxaldehyde (9CI)
• CAS NO: 112372-06-2
• Molecular Formula: C₈H₅NO₂
• Molecular Weight: 147.1308
• Product Categories: ALDEHYDE;PYRIDINE
• Mol File: 112372-06-2.mol

Chemical Properties

• Melting Point: 120.5-121 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 286.131°C at 760 mmHg (Cal.) ref.
• Flash Point: 126.848°C (Cal.) ref.
• Appearance: /
• Density: 1.323g/cm3 (Cal.) ref.
• PKA: 2.96±0.40(Predicted)
• CAS DataBase Reference: Furo[2,3-c]pyridine-2-carboxaldehyde (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[2,3-c]pyridine-2-carboxaldehyde (9CI)(112372-06-2)
• EPA Substance Registry System: Furo[2,3-c]pyridine-2-carboxaldehyde (9CI)(112372-06-2)

Safety Data

• Hazardous Substances Data: 112372-06-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Furo[2,3-c]pyridine-2-carboxaldehyde (9CI) is used as a key intermediate in the synthesis of pharmaceutical compounds for various therapeutic applications. Its unique structure and functional groups enable the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical industry, Furo[2,3-c]pyridine-2-carboxaldehyde (9CI) serves as a building block for the creation of novel agrochemicals, such as pesticides and herbicides. Its chemical properties allow for the design of more effective and targeted agrochemicals to enhance crop protection and yield.
Used in Organic Synthesis:
Furo[2,3-c]pyridine-2-carboxaldehyde (9CI) is used as a versatile building block in the synthesis of other organic compounds. Its presence in various chemical reactions allows for the creation of a wide range of molecules with diverse applications, from pharmaceuticals to materials science.
Used in Research and Development:
Furo[2,3-c]pyridine-2-carboxaldehyde (9CI) is utilized as a valuable tool in chemical research and development. Its unique structure and properties make it an ideal candidate for studying various chemical reactions and mechanisms, contributing to the advancement of scientific knowledge and the discovery of new compounds with potential applications.

Upstream product

• 19539-50-5 furo<2,3-c>pyridine 
• 109-94-4 formic acid ethyl ester 
• 84400-99-7 7-Chlorofuro[2,3-c]pyridine 
• 478148-77-5 2-(diethoxymethyl)furo[2,3-c]pyridine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 112372-15-3 furo<2,3-c>pyridine-2-carboxylic acid 
• 153863-91-3 2-aminomethylfuro<2,3-c>pyridine 
• 112372-12-0 2-cyanofuro<2,3-c>pyridine 
• 143707-99-7 5-Ethyl-3-[(furo[2,3-c]pyridin-2-ylmethyl)-amino]-6-methyl-1H-pyridin-2-one 
• 69022-76-0 2-methylfuro<2,3-c>pyridine 

Relevant articles and documents

FACTOR XIIA INHIBITORS

This invention relates to compoundsof formula (I)and methods of treatment using the compounds. The invention also relates to processes and methods for producing the compounds of the invention. The compounds of the invention are modulators of Factor XII (e.g. Factor XIIa). In particular, the compounds are inhibitors of Factor XIIa and may be useful as anticoagulants.

Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus

Efforts directed to identifying potent HIV protease inhibitors (PI) have yielded a class of compounds that are not only very active against wild-type (NL4-3) HIV virus but also very potent against a panel of PI-resistant viral isolates. Chemistry and biol

Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease

The invention provides compounds of Formula I: 1where in W is 2These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful to treat diseases or conditions in which α7 is known to be involved.

Synthesis and Evaluation of 2-Pyridinone Derivatives as HIV-1-Specific Reverse Transcriptase Inhibitors. 2. Analogues of 3-Aminopyridin-2(1H)-one

A series of nonnulceoside 3-aminopyridin-2(1H)-one derivatives was synthesized and evaluated for HIV-1 RT inhibitory properties.Several analogs proved to be potent and highly selective antagonists with in vitro IC50 values as low as 19 nM in the enzyme assay using rC*dG as template*primer.Two compounds from this series, 3-amino>-5-ethyl-6-methylpyridin-2(1H)-one (34, L-697,639) and the corresponding 4,7-dichloro analogue (37, L-697,661) inhibited the spread of HIV-1 IIIb infection by 95percent in MT4 cell culture at concentrations of 25-50 nM and were selected for clinical trials as antiviral agents.

Furopyridines. VII. Preparation and Hydrolysis of 2-Cyano and 3-Cyano Derivatives of Furo-, Furo-, and Furopyridine

This paper describes the preparation and hydrolysis of 2-cyano and 3-cyano derivatives of furo-, furo-, and furopyridine.Treatment of furopyridines 1a, 1b and 1c with n-butyllithium in hexane-tetrahydrofuran at -70 deg C and subsequent addition of N,N-dimethylformamide yielded 2-formyl derivatives 2a, 2b and 2c.Dehydration of the oximes 4a, 4b and 4c of 2a, 2b and 2c gave 2-cyano compounds 5a, 5b and 5c, which were hydrolyzed to give 2-carboxylic acids, 6a, 6b and 6c, respectively.Reaction of 3-bromo compounds 7a, 7b and 7c with copper(I) cyanide in N,N-dimethylformamide afforded 3-cyano derivatives 8a, 8b and 8c.Alkaline hydrolysis of 8a, 8b and 8c gave compounds formed by fission of the 1-2 bond of furopyridines 9a, 9b and 9c, while acidic hydrolysis gave the corresponding carboxamides, 10a, 10b and 10c.