1123785-35-2

Upstream product

• 1123785-30-7 (4R,5R,8S,E)-ethyl 9-(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4,8-dimethylnon-2-enoate 
• 1123785-11-4 (2R,3R,6S)-7-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2,6-dimethylheptan-1-ol 
• 1123785-63-6 (S)-4-benzyl-3-((2S,3R,6S)-7-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2,6-dimethylheptanoyl)oxazolidin-2-one 
• 180692-68-6 (S)-5-(phenylmethoxy)-4-methylpentanal 
• 391208-05-2 (S)-1-((2-methylpent-4-enyloxy)methyl)benzene 
• 100-39-0 benzyl bromide 
• 1123785-66-9 C₂₂H₃₈O₃Si 
• 887706-39-0 (S)-5-(benzyloxy)-4-methylpentan-1-ol 
• 943856-58-4 (S)-4-benzyl-3-((S)-2-methylpent-4-enoyl)oxazolidin-2-one 

Downstream Products

• 1123785-38-5 (4R,5R,8S,E)-ethyl 9-(benzyloxy)-4,8-dimethyl-5-((R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyloxy)non-2-enoate 
• 1123785-42-1 (4R,5R,8S,E)-ethyl-9-(benzyloxy)-4,8-dimethyl-5-((S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyloxy)non-2-enoate 

Relevant academic research and scientific papers

Asymmetric synthesis of a 12-membered macrolactone core and a 6-epi analogue of amphidinolide W from 4-pentenoic acid

A flexible and efficient asymmetric route to the synthesis of a 12-membered macrolactone core and a 6-epi analogue of amphidinolide W has been accomplished from commercially available 4-pentenoic acid. The successful generation of stereocenters was achieved by utilizing an Evans' chiral auxiliary-based alkylation and aldol reaction. Other key reactions such as a Julia-Kocienski olefination, Kita's macrolactonization, ring closing metathesis (RCM) reaction, and Yamaguchi's esterification were significant for the construction of the macrolactone cores.