1123785-85-2

Upstream product

• 1123785-30-7 (4R,5R,8S,E)-ethyl 9-(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4,8-dimethylnon-2-enoate 
• 1123785-11-4 (2R,3R,6S)-7-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2,6-dimethylheptan-1-ol 
• 180692-68-6 (S)-5-(phenylmethoxy)-4-methylpentanal 
• 391208-05-2 (S)-1-((2-methylpent-4-enyloxy)methyl)benzene 
• 100-39-0 benzyl bromide 
• 1123785-76-1 C₃₁H₄₈N₄O₂SSi 
• 1123785-66-9 C₂₂H₃₈O₃Si 
• 5673-98-3 (S)-(-)-2-methyl-4-penten-1-ol 
• 887706-39-0 (S)-5-(benzyloxy)-4-methylpentan-1-ol 
• 1123785-51-2 (2S,7R,8R,11S,3E)-8-(tert-butyldimethylsilyloxy)-7,11-dimethyldodec-3-en-1,2,12-triol 
• 1123785-82-9 (2S,7R,8R,11S,E)-12-(benzyloxy)-8-(tert-butyldimethylsilyloxy)-7,11-dimethyldodec-3-ene-1,2-diol 
• 1123785-48-7 ((2S,5R,6R,9E)-1-(benzyloxy)-10-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,6-dimethyldec-9-en-5-yloxy)(tert-butyl)dimethylsilane 
• 1123785-06-7 5-((4R,5R,8S,)-9-(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4,8-dimethylnonylsulfonyl)-1-phenyl-1H-tetrazole 
• 1123785-54-5 (2S,5R,6R,11S,9E)-12-(benzyloxy)-5-(tert-butyldimethylsilyloxy)-2,6-dimethyldodec-9-en-1,11-diol 

Downstream Products

• 1123785-57-8 (2S,5R,6R,11S,9E)-12-(benzyloxy)-5-(tert-butyldimethylsilyloxy)-11-hydroxy-2,6-dimethyldodec-9-enoic acid 
• 1123785-03-4 (3S,6R,7R,12S,10E)-12-(benzyloxymethyl)-6-(tert-butyldimethylsilyloxy)-3,7-dimethyloxacyclododec-10-en-2-one 
• 1123785-59-0 (3R,6R,7R,12S,10E)-12-(benzyloxymethyl)-6-(tert-butyldimethylsilyloxy)-3,7-dimethyloxacyclododec-10-en-2-one 

Relevant academic research and scientific papers

Asymmetric synthesis of a 12-membered macrolactone core and a 6-epi analogue of amphidinolide W from 4-pentenoic acid

A flexible and efficient asymmetric route to the synthesis of a 12-membered macrolactone core and a 6-epi analogue of amphidinolide W has been accomplished from commercially available 4-pentenoic acid. The successful generation of stereocenters was achieved by utilizing an Evans' chiral auxiliary-based alkylation and aldol reaction. Other key reactions such as a Julia-Kocienski olefination, Kita's macrolactonization, ring closing metathesis (RCM) reaction, and Yamaguchi's esterification were significant for the construction of the macrolactone cores.

Highly stereoselective approach toward the synthesis of the macrolactone core of amphidinolide W

The diastereoselective synthesis of the macrolactone core of amphidinolide W was successfully accomplished using Evans' asymmetric alkylation, Aldol reaction, Julia-Kocienski olefination, and Kita's macrocyclization protocol.