112391-04-5Relevant articles and documents
Synthesis of 1'-Methylspiro from 1-Methyl-n-piperidinecarbaldehydes
Benito, Y.,Canoira, L.,Martinez-Lopez, N.,Rodriguez, J. G.,Temprano, F.
, p. 623 - 628 (2007/10/02)
1'-Methylspiro 2 can be obtained from 1-methyl-n-piperidinecarbaldehydes 1 by the Fischer reaction of their phenylhydrazones.The Fischer reaction provides different kinds of products -3H-indole, indole and oxindole- which depend on the N atom position in the piperidine ring.
Neuromuscular blocking agents and antagonists
-
, (2008/06/13)
It is disclosed that 2-(4''-pyridyl)-1,3-dioxolane methiodide and 2-(1''-methyl-4''-piperidyl)-1,3-dioxolane hydroiodide are neuromuscular blocking agents or neuromuscular blocking agent antagonists, depending upon the amount of the drug administered.At doses of 10 - 6 to 10 - 4 gm./kg. of body weight, they antagonize or reverse the effects of neuromuscular blocking agents, such as d-tubocurarine and succinylcholine, produce post-drug repetitive activity (PDR), block post-tetanic potentiation (PTP), have no direct muscle effect and reverse the PTP suppression caused by d-tubocurarine and succinylcholine; and at doses of 10 - 3 to 10 - 2 gm./kg. of body weight they act as neuromuscular blocking agents.