58795-05-4Relevant academic research and scientific papers
Synthesis and unusual stability of pyridine and N-methyl pyridinium 1,3-dioxolanes
Hobson, Stephen T.,Boecker, Joseph D.,Gifford, James H.,Nohe, Tara L.,Wierks, Carl H.
, p. 277 - 282 (2007/10/03)
Differentially substituted bridged pyridinium oximes are necessary in research on antidotes for organophosphate poisoning. A solid-phase synthesis would improve the yield and ease of purification of these compounds. To predict the lability of the linker in the final step of our proposed synthesis, we synthesized a series of pyridine and N-methyl pyridinium acetals. These compounds proved to be resistant to acid catalyzed hydrolysis. This stability may be useful for synthetic manipulation of pyridine aldehydes.
Reduction of n-(1,3-Dioxolan-2-yl)-1-methylpyridinium Ions: Molecular Structure of the 4-(1,3-Dioxolan-2-yl)-1-methyl-1,2,3,6-tetrahydropyridine-Borane Complex
Rodriguez, J. G.,Martinez-Lopez, N.,Lerma, J. Lopez de,Perales, A.
, p. 135 - 139 (2007/10/02)
The reduction of the n-(1,3-dioxolan-2-yl)-1-methylpyridinium ions with sodium borohydride has been studied to prepare N-methylformylpiperidines.Deuterium oxide was used as the solvent in order to assign the protons in the nmr spectra.As a product of the reaction, the 4-(1,3-dioxolan-2-yl)-1-methyl-1,2,3,6-tetrahydropyridine-borane complex, was isolated and crystallized.A X-ray study of this borane complex has been carried out.
Synthesis of 1'-Methylspiro from 1-Methyl-n-piperidinecarbaldehydes
Benito, Y.,Canoira, L.,Martinez-Lopez, N.,Rodriguez, J. G.,Temprano, F.
, p. 623 - 628 (2007/10/02)
1'-Methylspiro 2 can be obtained from 1-methyl-n-piperidinecarbaldehydes 1 by the Fischer reaction of their phenylhydrazones.The Fischer reaction provides different kinds of products -3H-indole, indole and oxindole- which depend on the N atom position in the piperidine ring.
Neuromuscular blocking agents and antagonists
-
, (2008/06/13)
It is disclosed that 2-(4''-pyridyl)-1,3-dioxolane methiodide and 2-(1''-methyl-4''-piperidyl)-1,3-dioxolane hydroiodide are neuromuscular blocking agents or neuromuscular blocking agent antagonists, depending upon the amount of the drug administered.At doses of 10 - 6 to 10 - 4 gm./kg. of body weight, they antagonize or reverse the effects of neuromuscular blocking agents, such as d-tubocurarine and succinylcholine, produce post-drug repetitive activity (PDR), block post-tetanic potentiation (PTP), have no direct muscle effect and reverse the PTP suppression caused by d-tubocurarine and succinylcholine; and at doses of 10 - 3 to 10 - 2 gm./kg. of body weight they act as neuromuscular blocking agents.
