58795-05-4Relevant articles and documents
Synthesis and unusual stability of pyridine and N-methyl pyridinium 1,3-dioxolanes
Hobson, Stephen T.,Boecker, Joseph D.,Gifford, James H.,Nohe, Tara L.,Wierks, Carl H.
, p. 277 - 282 (2007/10/03)
Differentially substituted bridged pyridinium oximes are necessary in research on antidotes for organophosphate poisoning. A solid-phase synthesis would improve the yield and ease of purification of these compounds. To predict the lability of the linker in the final step of our proposed synthesis, we synthesized a series of pyridine and N-methyl pyridinium acetals. These compounds proved to be resistant to acid catalyzed hydrolysis. This stability may be useful for synthetic manipulation of pyridine aldehydes.
Synthesis of 1'-Methylspiro from 1-Methyl-n-piperidinecarbaldehydes
Benito, Y.,Canoira, L.,Martinez-Lopez, N.,Rodriguez, J. G.,Temprano, F.
, p. 623 - 628 (2007/10/02)
1'-Methylspiro 2 can be obtained from 1-methyl-n-piperidinecarbaldehydes 1 by the Fischer reaction of their phenylhydrazones.The Fischer reaction provides different kinds of products -3H-indole, indole and oxindole- which depend on the N atom position in the piperidine ring.
