112421-89-3Relevant academic research and scientific papers
Modular synthesis of phenanthridine derivatives by oxidative cyclization of 2-isocyanobiphenyls with organoboron reagents
Tobisu, Mamoru,Koh, Keika,Furukawa, Takayuki,Chatani, Naoto
supporting information, p. 11363 - 11366 (2013/01/15)
Where HAS you been? A manganese-mediated annulation of 2-isocyanobiaryls with organoboronic acids is developed for the synthesis of a broad range of phenanthridine derivatives (see scheme). Mechanistic studies indicate that the reaction proceeds by the intramolecular homolytic aromatic substitution (HAS) of an imidoyl radical intermediate. Copyright
Potential Antitumor Agents. 55. 6-Phenylphenanthridine-4-carboxamides: A New Class of DNA-Intercalating Antitumor Agents
Atwell, Graham J.,Baguley, Bruce C.,Denny, William A.
, p. 774 - 779 (2007/10/02)
Derivatives of the DNA-intercalating agent N-phenanthridine-4-carboxamide (7) have been prepared and shown to have moderate in vivo antitumor activity against both the P388 leukemia and Lewis lung carcinoma.This demonstrates that t
