112423-14-0

Upstream product

• 571168-90-6 3-iodo-4-methoxy-1-methylpyridin-2(1H)-one 
• 98-80-6 phenylboronic acid 
• 4214-78-2 5-chloro-1-methylpyridin-2(1H)-one 
• 41759-19-7 4-methoxy-1-methyl-2-pyridone 
• 112423-09-3 8,8-Dimethoxy-6-methyl-4-phenyl-2-oxa-6-azabicyclo<2.2.2>octan-3,5-dion 

Downstream Products

• 1169878-18-5 C₁₃H₁₂INO₂ 

Relevant academic research and scientific papers

Highly c3-selective direct alkylation and arylation of 2-pyridones under visible-light-promoted photoredox catalysis

An Ir photoredox catalyst-mediated highly site-selective direct alkylation and arylation of 2-pyridones has been developed. Under visible-light-promoted conditions, ethyl 2-bromo-2,2-difluoroacetate couples with various 2-pyridones exclusively at the C3 position. A similar photoredox catalysis is also effective for the direct C3- Arylation with diaryliodonium triflates. Thus, these reactions occurs under very mild conditions (blue LEDs irradiation and ambient temperature) to form the corresponding C3- Alkylated and arylated 2-pyridones of potential interest in medicinal and pharmaceutical chemistry.

Manganese-mediated C3-selective direct alkylation and arylation of 2-pyridones with diethyl malonates and arylboronic acids

A manganese-mediated dehydrogenative direct alkylation of 2-pyridones with diethyl malonates has been developed. A similar reaction system is applicable to the direct arylation with arylboronic acids. These manganese-based reactions occur regioselectively at the C3 position of the 2-pyridones. The observed high C3 regioselectivity can complement precedented C-H functionalization protocols of the 2-pyridones in view of the site selectivity.

A convenient access to furo[3,2-c]pyridin-6(5H)-ones by the reaction of 5-iodo-4-methoxy-2-pyridones with terminal alkynes under microwave-enhanced Sonogashira conditions

N-Alkyl-3-aryl-5-iodo-4-methoxypyridin-2(1H)-ones readily undergo sequential acetylide cross-coupling, demethylation, and furan annulation under classical Sonogashira reaction conditions to furnish 7-arylfuro[3,2-c]pyridin-4(5H)-ones, a class of hitherto

Novel 1,4-Dipolar Cycloaddition Reactions of 6-Oxo-6H-1,3-oxazin-3-ium-4-olates and of a 6-Oxo-6H-1,3-thiazin-3-ium-4-olate to Ketene Derivatives and Enamines

The reactions of the ketene derivatives 4, 7, and 9 as well as of the enamines 13 and 17 with some selected title compounds are described.In these cases either primary adducts of type 5, 14, or 20 are produced by a 1,4-dipolar cycloaddition, or subsequent eliminations proceed with formation of products of type 8, 11, 16, or 18.The 2(1H)-pyridinones 8 are formed by thermolysis of 5, whereas 15a-d are accessible on treatment of 14a-d or 20 with acid.The observed regioselectivities are compared with the results of MNDO calculations and the FMO and PMO theory.